Center for Spatial Omics

The Center of Spatial Omics (CSO) enables high-resolution, highly multiplexed spatial analysis of gene and protein expression within intact tissues, providing St. Jude investigators with access to molecular information at a scale and level of context not achievable with conventional approaches. The Center uniquely supports simultaneous measurement of hundreds to thousands of RNA targets—up to whole-transcriptome profiling—as well as high-plex protein detection ranging from tens to over a thousand markers in a single experiment. This depth of multiplexing allows comprehensive mapping of cellular states, signaling pathways, and cell–cell interactions within complex tumor and tissue microenvironments. By integrating advanced spatial platforms with expert study design, standardized workflows, and end-to-end analytical support, the center enhances rigor and reproducibility and accelerates high-impact basic, translational, and clinical research across St. Jude.