St. Jude Reference #SJ-20-0009
Description
There is no clinical therapeutic to stop the progression of neurodegenerative diseases or that preserves brain function during aging. A collapse in proteostasis and loss of protein quality control are important causes of age-related neurodegenerative diseases (such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and others). Neurodegeneration in the central nervous system (CNS) is a defining sign of aging that is influenced by peripheral tissues. Clinical observations indicate skeletal muscle influences CNS aging, but the signaling remains unexplored.
Studying proteostasis in fruit flies (Drosophila) and human brain organoids, researchers at St. Jude found a protective stress response that through muscle-secreted Amyrel amylase signaling preserves protein quality control in the retina and brain during aging. Their work indicates that Amylase, SLC45 maltose transporters, and maltose-based therapies may oppose and retard the development of neurodegenerative diseases by preventing the accumulation of faulty (misfolded) proteins and protein aggregates in the retina and brain during aging. Their invention consists of amylase- and maltose-based interventions for preserving protein quality control and tissue function during aging and for preventing age- and disease-associated neurodegeneration via amylase/maltose-induced signaling.
Keywords
Muscle-to-brain signaling, aging, myokine, proteasome, stress response, proteostasis, amylase, maltose, brain organoids, muscle-to-retina signaling, Alzheimer, Parkinson, Huntington.
Granted patents or published applications
Application filed, available under confidentiality
Related scientific references
Mamta Rai, Zane Coleman, Michelle Curley, Anjana Nityanandam, Fabio Demontis. “Proteasome stress in skeletal muscle mounts a long-range protective response that delays retinal and brain aging.”
Rai et al., 2021, Cell Metabolism 33, 1137–1154
June 1, 2021 Elsevier Inc.
https://doi.org/10.1016/j.cmet.2021.03.005
Licensing opportunities
We are seeking partners to develop amylase- and maltose-based interventions (including nutraceutical approaches, injection of recombinant amylase, and gene therapy to boost levels of amylase and/or of SLC45 maltose transporters) for preserving protein quality control and tissue function during aging and for preventing age- and disease-associated neurodegeneration via amylase/maltose-induced signaling. Contact: chad.riggs@stjude.org
Contact the Office of Technology Licensing (Phone: 901-595-2342, Fax: 901-595-3148) for more information.