St. Jude Reference #SJ-20-0026
Description
Researchers at St. Jude identified hundreds of human genome DNA fragments with strong enhancer blocking activities in lymphocytes.
These insulators can be incorporated into viral vectors to prevent enhancer mediated oncogene activation by vector enhancer elements, and thus enhance the safety of the vectors. These safer vectors can be used therapeutically to treat a variety of different diseases.
Keywords
Genome, DNA, fragment, enhancer blocking activity, lymphocytes. Biologic, viral vector, insulator, cancer
Granted patents or published applications
Pending international application published as WO 2021/231192
Related scientific references
Licensing opportunities
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Contact the Office of Technology Licensing (Phone: 901-595-2342, Fax: 901-595-3148) for more information.