St. Jude Reference #SJ-13-0012
Boosting the ability of regulatory T cells by blocking an effective anti-tumor immune response led to the elimination or dramatic reduction of melanoma by the immune system in mice, without causing the autoimmune and inflammatory problems often associated with current cancer-treatment efforts that target immune regulators. The mechanism is built around two proteins. One, semaphorin-4a (Sema4a), is carried on the surface of various immune cells that can spark inflammation. The other, neuropilin-1 (Nrp1), is carried on the surface of regulatory T cells.
Regulatory T cell (Treg), Neuropiln 1 (Nrp1), Semaphorin-4a (Sema4a), tumor-induced tolerance, tumor resistance, autoimmune, inflammation, cancer, immunotherapeutic.
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'Regulatory T cell stability is maintained by a neuropilin-1:semaphorin-4a axis' is published on Nature.com: http://dx.doi.org/10.1038/nature12428
(Abstracts are available to everyone, full text only to subscribers; relevant references are cited in the paper and can be provided on request).
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