St. Jude Reference #SJ-11-0014
A research team here at St. Jude, led by Howard Hughes Medical Investigator Brenda Schulman, PhD, have discovered a peptide that inhibits cullin neddylation, a process required for proper cell proliferation. It could be useful for drug screening and peptide screening applications; which could have therapeutic potential for treating cancer, inflammatory disorders and/or or pathogenic infections.
Peptide inhibitor, screening method, drug discovery, enzyme, cancer, pathogen, inflammation
Granted patents or published applications
An Issued US Patent application, 9,447,156; covers this peptide, its pharmaceutical use and screening methods for identifying additional inhibitors
Related scientific references
The research underlying this discovery was reported as Scott, D.C. et al., Science 334: 674-678 (Nov. 4, 2011).
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