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How T cells respond to vaccination against COVID-19
12/29/2021
Scientists at St. Jude and Washington University School of Medicine in St. Louis are learning how the immune system responds to mRNA vaccination.
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Biologic features help cells stay organized
12/20/2021
Structural biologists at St. Jude created a model to predict phase separation among proteins in cells.
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Phase separation process helps leukemia develop
12/13/2021
Scientists at St. Jude have revealed how a process used by cells to organize proteins is essential to the formation of leukemia by fusion oncoproteins.
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Understanding the global burden of adolescent cancer
12/08/2021
Adolescents are often overlooked in worldwide cancer policy. St. Jude researchers are working with over 700 international colleagues to highlight their needs.
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‘Astounding’ results reported for children with high-risk neuroblastoma
12/07/2021
The monoclonal antibody called hu14.18K322A is made on the St. Jude campus, and works by attaching to the surface of the tumor and revving up the immune response to kill the tumor cells.
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Activating ALK: Ligand binding holds the key
11/24/2021
St. Jude Children’s Research Hospital scientists have shed light on the way ligands bind to and activate ALK, an important target for cancer drug development.
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Sending neuroblastoma cells to the trash
11/12/2021
Scientists at St. Jude and Dana-Farber Cancer Institute created a compound to selectively degrade the EP300 enzyme that neuroblastoma cells need to survive.
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Biomarker predicts medulloblastoma relapse
10/21/2021
St. Jude scientists developed a test to look for signals that identify the presence of cell-free DNA from medulloblastoma.
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Changing tumor cell identity
10/20/2021
Scientists at St. Jude and Dana-Farber Cancer Institute learned how retinoic acid changes tumor cells in children with high-risk neuroblastoma.
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DNA damage causes neurological syndrome
10/15/2021
St. Jude scientists found that a DNA repair system breakdown is to blame for Aicardi-Goutières syndrome (AGS).
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Figuring out how T cells interpret signals
10/12/2021
St. Jude scientists are studying how cytokines that promote inflammatory responses affect T cells.
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Learning from ‘natural gene therapy’
10/07/2021
St. Jude scientists worked with researchers in Europe to learn how they might be able to manipulate SAMD9 and SAMD9L genes to the advantage of the patients.
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Meet the PANoptosome
09/01/2021
St. Jude scientists found that inflammasomes can work with other cell death pathway molecules, resulting in a mega-cell death complex called a PANoptosome.
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COVID-19 worse in children with cancer
08/26/2021
Scientists at St. Jude and the International Society of Paediatric Oncology created a global registry to study how the COVID-19 pandemic affects children with cancer.
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Research tool builds neighborhoods of data
08/23/2021
St. Jude scientists created a tool to compare T-cell receptor sequence and gene-expression data.
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Every patient’s cancer tells a unique genomic story
07/30/2021
St. Jude scientists decoded and analyzed genomic material from both tumors and normal cells to better identify mutations.
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Molecular groups give context to clinical results
07/22/2021
St. Jude scientists looked at tumor samples from a Children’s Oncology Group clinical trial and assigned participants to molecular groups. The findings changed how the trial’s results were interpreted.
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Visualizing moving molecules
07/07/2021
St. Jude researchers are trying to visualize and better understand the movements of the ribosome.
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A pathway to balance revealed
07/07/2021
St. Jude scientists found a metabolic control pathway that regulates how specialized immune cells develop.
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Studies show what stressed cells need to recover
06/24/2021
St. Jude scientists are trying to understand cell stress responses and how it applies to neurodegenerative diseases.
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Finding the genetic driver of a hard-to-classify leukemia
06/22/2021
Scientists at St. Jude and the Munich Leukemia Laboratory found a new subtype of leukemia.
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Method reveals secrets of drug receptors in cells
06/15/2021
Scientists at St. Jude and Columbia University worked together to create a tracking system that can follow drug receptors moving along living cell membranes.
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Researchers go deep to understand treatment response
06/10/2021
St. Jude scientists analyzed tumor samples from a 10-year clinical trial that studied medulloblastoma.
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Collaboration controls killers
06/04/2021
Scientists at St. Jude looked at sequences of DNA to determine how they can destroy cancer cells that resist treatment.
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Genetic base editing shows promise for treatment of sickle cell disease
06/03/2021
St. Jude Children's Research Hospital scientists have helped advance a new therapy for sickle cell disease.
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Cost calculation aims to promote discussion about drug prices
06/03/2021
A St. Jude analysis found a gap between the cost of manufacturing and distribution for hemophilia B gene therapy.
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By age 10, retinoblastoma patients’ learning and life skills rebound
04/29/2021
St. Jude researchers found that retinoblastoma survivors functioned within the normal range of learning and life skills after five years.
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Signals from muscle protect from dementia
03/26/2021
Scientists at St. Jude are studying how signals sent from skeletal muscle affect the brain.
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Socioeconomic status plays a major role in cognitive outcomes
03/01/2021
St. Jude scientists are studying the risk factors associated with cancer treatments and its effects on cognition.
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A genomic map to therapy-related blood cancers
02/12/2021
St. Jude scientists are studying mutations that lead to a certain kind of treatment-related blood cancer.
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Challenging dogma about a relapsed brain tumor
01/27/2021
St. Jude scientists are studying the molecular mechanisms responsible for medulloblastoma treatment failure and recurrence.
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Instruments err. This tool identifies the mistakes.
01/25/2021
St. Jude scientists created a free mathematical tool to find instrument-caused errors.
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COVID-19 poses a serious risk to bone marrow transplant recipients
01/19/2021
St. Jude scientists are discovering that children and adults who receive bone marrow transplants should make COVID-19 prevention a priority.
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Machine learning gives research a leg up
01/19/2021
St. Jude scientists developed deep learning to add to machine learning methods, which helps grow cancer research tools.
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What’s to be learned by ‘painting’ the cancer genome? Plenty!
01/11/2021
St. Jude scientists helped develop a web-based tool to offer researchers the ability to analyze genomic data.
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Results published on medulloblastoma clinical trial
01/08/2021
St. Jude researchers find more insight into medulloblastoma molecular groups to determine treatment for patients.
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Massive cloud eases genomic data sharing
01/06/2021
St. Jude researchers developed a cloud-based, data-sharing platform, which is the world’s largest pediatric cancer genomic data resource.
