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21st Workshop: Pathology of Mouse Models for Human Disease

Monday - Friday, September 9 - 13, 2024
Marlo Thomas Center for Global Education and Collaboration
St. Jude Children’s Research Hospital
Memphis, Tennessee

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Summary

The goal of this 5-day workshop is to provide intense interactive sessions aimed at training the next generation of comparative pathologists and biomedical scientists who will be involved in the development and use of mouse models of human disease. The workshop will focus on how mouse models of human diseases are being used in basic research and preclinical studies addressing the pathogenesis and/or efficacy of novel treatments. 

The workshop will be led by a group of experienced comparative pathologists from several research institutions across the U.S. who specialize in mouse model use and development. Additional training will be provided by invited experts as well as St. Jude faculty that currently use mouse models to investigate fundamental questions in immunology, cancer pathogenesis and treatment, infectious disease, neurodegenerative disease, and developmental biology. The workshop will include training in the application of the latest technologies available to comparative pathologists who are investigating disease pathogenesis and novel therapeutics in basic and translational research. 

The mouse is heavily utilized as a model of human diseases, and there are increasing demands on pathologists to provide clinically relevant, quantitative morphological and molecular data on mouse models. Given the increasing need for quantitative analysis of lesions in whole slide images, the last day of the workshop will include 8 hours of hands-on bioimage analysis training targeted at scientists who want to analyze microscopy data, but do not have a background in programming or image analysis. 

View the Workshop Agenda   Agenda

Registration

Deadline for in-person: Friday, September 1, 2024
Deadline for virtual: Friday, September 6, 2024

  • In-person (limited to 50 attendees): $1,000 USD; trainees $750
  • Virtual or On Demand: $300

Register

Cancellation Policy

In-person meeting cancellations will incur a $200 cancellation fee. For Virtual attendees, the registration fee will be refunded less a $100 processing fee. All cancellation requests must be received in writing mousemodelpathology@stjude.org and submitted no later than August 9, 2024. No refund requests received after that date will be processed. Even If you cannot attend the in-person meeting due to travel restrictions by your company/country or other unforeseen circumstances we will be unable to give a full refund. Refund requests received after August 9, 2024, cannot be processed and will result in forfeiture of the registration fees.

    • Both In-person and Virtual registration include On Demand access.
    • On Demand recordings will be available approximately 1-2 weeks after the meeting has concluded. Access to On Demand recordings will last for a period of 90 days from the end of the meeting.
    • Virtual attendance and On Demand access will include presentations from the main session room ONLY. We will not live stream or record the image analysis training sessions.
    • We want to provide access to all of the oral presentations of the meeting for the On Demand audiences. However, some speakers may opt-out of recording their presentations for On Demand access. We are encouraging all speakers to share their presentations with the On Demand audience but must respect the decision of any who chose not to do so.
  1. The Organizing Committee wishes to provide an opportunity for attendees (pathology residents, graduate students, post-doctoral fellows) to present their research or interesting cases at this Workshop. We invite you to participate and look forward to an active exchange of thoughts and experiences (maximum 15 minutes presentation plus 5 for questions). Please submit brief abstracts for consideration and inclusion in the scientific program as an oral presentation. The submitted abstracts should give a brief description of the title and topic. All abstracts must be submitted no later than July 15, 2024, and will be reviewed by members of the organizing committee. Participants will be notified by August 4, 2024, if their abstract is accepted. It is best to submit your abstract as early as possible because spaces are limited for abstracts and in-person registration and may fill up well before the indicated deadlines. 

    Submit an Abstract

    • R.A.C.E. (Registry of Approved Continuing Education) credits:  This program has been approved for 20 hours of continuing education credit in jurisdictions which recognize RACE approval
    • ACVP board-certified pathologists, MoC (Maintenance of Certification) credit
  2. The workshop will be held on the campus of St. Jude Children’s Research Hospital, which is the only National Cancer Institute-designated Comprehensive Cancer Center devoted solely to children. The mission of St. Jude Children's Research Hospital is to advance cures, and means of prevention, for pediatric catastrophic diseases through research and treatment. 

    For helpful tips on what you might want to see or do in Memphis if you arrive early or stay after the meeting, check out the official source for the best Memphis experiences and activities: memphistravel.com

    Parking Notes

    A shuttle between the hotel and campus will be provided.  If you are driving to Memphis and require onsite parking please let us know in advance.

    Food and Dining Notes

    The Hotel provides a simple buffet breakfast each day. Lunch will be provided daily

    We are organizing an evening riverboat cruise with dinner. More information will be available as soon as it is planned.

  3. Memphis International Airport (MEM)

    Address: 2491 Winchester Rd, Memphis, TN 38116
    Distance from hotel to airport: 11 Miles
    Estimated drive time: 16 Minutes
    Airport Shuttle: N/A
    Taxi: Approximately $30
    Uber: Approximately $26 or higher, depending on timing

    Weather/Conference Attire

    The average high for Memphis in September is 85°F; average low is 66°F. Meeting room temperatures tend to be cool so attendees should bring a light sweater or jacket to all activities. 

    Personal Safety and Security

    • Always remove your meeting badge before leaving the hotel. 
    • Don’t leave personal property unattended anywhere, anytime.
    • Be aware of your surroundings at all times. Avoid wearing headphones or looking at electronic devices while walking, especially outside the hotel.
    • Use the buddy system when walking to and from the hotel. If you are alone, consider using a taxi or ride-share service. 
    • If traveling off-site, let someone know where you are going, when you expect to be back, and how to reach you.
    • Use the deadbolt lock on your hotel room door when inside; do not leave the door ajar if you are expecting visitors/guests.
    • Practice responsible consumption of alcoholic beverages.
 
 

Detailed Agenda

Download the full agenda   Download

  1. Monday, September 9
    Mouse model resources and pathology methods
    8:00-8:30 am Registration
    8:30-8:45 am

    Welcome to the 21st Workshop on Pathology of Mouse Models for Human Diseases

    Laura Janke, DVM, PhD, DACVP
    Director, Division of Comparative Pathology
    St. Jude Children's Research Hospital

    8:45-9:15 am

    Access to Genetically Engineered Mouse Resources – What You Need to Know! and What You Need to Know About NIH - a Short Overview and Guide for Trainees [remote presentation]

    Franziska Grieder, DVM, PhD
    Director of Office of Research Infrastructure Programs
    NIH

    9:15-10:00 am

    Concepts on Mouse Models for Human Diseases and A Pathologist’s Approach to Phenotyping Mutant Mice

    John P. Sundberg, DVM, PhD, DACVP
    The Jackson Laboratory and Vanderbilt University Medical Center

    10:00-10:15 am Break
    10:15-11:00 am

    New and Emerging Genetic Engineering Technologies for Creating Preclinical Models of Human Disease

    Shondra Miller, PhD
    Director, Transgenic/Gene Knockout Shared Resource
    St. Jude Children's Research Hospital

    11:00-11:45 am

    Mouse Genetic Nomenclature: The Underpinning of Mouse Genetics

    John P. Sundberg, DVM, PhD, DACVP
    The Jackson Laboratory and Vanderbilt University Medical Center

    11:45 am-1:00 pm Lunch break (Lunch included with registration)
    1:00-1:45 pm Attendee presentations (2 x 20 minutes each)
    1:45-2:30 pm

    Advantages of Inbred, Diversity Outbred, and Collaborative Cross Mice

    Gillian Beamer, DVM, PhD, DACVP
    Texas Biomedical Research Institute
    J&J Innovative Medicine

    2:30-3:15 pm

    Pathology of the Testis/Male Infertility in Mice: Relevance to Drug Development

    Hibret Adissu, DVM, PhD, DACVP
    Director, Pathology
    AstraZeneca 

    3:15-3:30 pm Break
    3:30-4:15 pm

    Ciliopathies

    Peter Vogel, DVM, PhD, DACVP
    Member, St. Jude Children's Research Hospital

    4:15-5:00 pm

    Requirements for Success in ISH/IHC/IF Studies

    Allesandra Piersigilli, DVM, PhD, DACVP
    Takeda Development Center Americas, Inc.

     

  2. Tuesday, September 10
    Pathology assessment of mouse models of human cancer
    8:30-9:15 am

    Overview of Mouse Cancer Models

    Katherine Gibson-Corley, DVM, PhD, DACVP
    Professor, Vanderbilt University Medical Center

    9:15-10:00 am

    Mouse Models of Pediatric Solid and Brain Tumors

    Heather Sheppard, DVM, PhD, DACVP
    Associate Member, St. Jude Children's Research Hospital

    10:00-10:15 am Break
    11:00-11:30 am

    TBD

    Jerry Rehg, DVM, DACVP
    Emeritus
    St. Jude Children's Research Hospital

    11:30 am-12:00 pm Attendee presentations (3 x 20 minutes each)
    12:00-1:00 pm Lunch break (Lunch included with registration)
    1:00-1:45 pm

    Evaluation of the mouse embryo and placenta – roles of genes in development

    Jerrold M. Ward, DVM, PhD, DACVP
    Global VetPathology

    1:45-2:30 pm

    Next Generation CAR T Cells for the Immunotherapy of High-Grade Glioma

    Giedre Krenciute, PhD
    Assistant Member, St. Jude Children’s Research Hospital

    2:30-3:15 pm

    Safety Assessment of CAR T cell Therapies

    Allesandra Piersigilli DVM, PhD, DECVP
    Takeda Development Center Americas, Inc. 

    3:15-3:30 pm Break
    3:30-4:15 pm

    Recognition of Aberrant Immune Cell Proliferations in Immunocompromised Mice Receiving Human Cells [remote presentation]

    Pedro Ruivo, DVM, MSc, DACVP,
    UC Davis School of Veterinary Medicine

    4:15-5:00 pm

    Tips and Tricks in Mouse Pathology: Refining mouse models of human disease

    Jerrold M. Ward, DVM, PhD, DACVP
    Global VetPathology

    6:00-8:00 pm Memphis Barbecue Dinner (Included with registration)
  3. Wednesday, September 11
    Pathology assessment of mouse models of inflammation and infectious disease 
    8:30-9:00 am

    Comparative Pathology of Chronic Kidney Diseases

    Karyn E. Enos, DVM, MS, DACVP
    Novartis Institutes for Biomedical Research, Cambridge, MA

    9:00-9:30 am

    Comparative Pathology of Metabolic Dysfunction-associated Steatotic Liver Disease

    Karyn E. Enos, DVM, PhD, DACVP
    Novartis Institutes for Biomedical Research 

    9:30-10:00 am

    Comparative Pathology of Fibrotic Lung Diseases

    Karyn E. Enos, DVM, PhD, DACVP
    Novartis Institutes for Biomedical Research

    10:00-10:15 am Break
    10:15-11:00 am

    Modeling Complex Infections in the Murine Respiratory Tract

    Jason Rosch, PhD
    Associate Member, St. Jude Children’s Research Hospital

    11:00-11:45 am

    TBD

    Jeremy Jones, PhD
    Member, St. Jude Children’s Research Hospital

    11:45 am-1:00 pm Lunch break (Lunch included with registration)
    1:00-2:30 pm Tour of St. Jude Children's Research Hospital
    2:30-3:15 pm

    Complex Genetics of Susceptibility to Tuberculosis Infection

    Gillian Beamer, DVM, PhD, DACVP
    Texas Biomedical Research Institute & J&J Innovative Medicine

    3:15-3:30 pm Break
    3:30-4:15 pm

    Innate lymphoid Cells: Their Role in Inflammatory Diseases

    Harm HogenEsch, DVM, PhD
    Purdue University

    4:15-5:00 pm

    Immunofluorescence Microscopy in Preclinical Mouse Models [remote presentation]

    Tiffany Lyle, DVM, PhD, DACVP
    Cook Research Incorporated

     

  4. Thursday, September 12
    Pathology assessment of mouse models of neurological disease
    8:30-9:15 am

    Pathology Phenotyping of the Central Nervous System in Mice

    Caroline Zeiss, DVM, PhD, DACVP
    Yale School of Medicine

    9:15-10:00 am

    Mouse of Models of Neurodegenerative Disease

    Caroline Zeiss, DVM, PhD, DACVP
    Yale School of Medicine

    10:00-10:15 am Break
    10:15-11:00 am

    Neuromuscular Disease Phenotyping and Models

    Peter Vogel, DVM, PhD, DACVP
    St. Jude Children's Research Hospital

    11:00 am-12:00 pm

    Mouse Models of Brain Metastases

    Tiffany Lyle DVM, PhD, DACVP
    Cook Research Incorporated

    12:00-1:00 pm Lunch break (Lunch included with registration)
    1:00-1:45 pm

    Eye Disease Models

    Peter Vogel, DVM, PhD, DACVP
    St. Jude Children's Research Hospital

    1:45-2:30 pm

    Experimental Autoimmune Encephalomyelitis (EAE) as a Model for Multiple Sclerosis (MS)

    Katherine Gibson-Corley, DVM, PhD, DACVP
    Vanderbilt University Medical Center

    2:30-3:15 pm

    Applications of humanized mice

    Kelli Boyd, DVM, PhD, DACVP
    Gilead Sciences

    3:15-3:30 pm Break
    3:30-3:55 pm

    Examples of mouse models in nonclinical discovery and safety assessment

    Anoop Kavirayani, BVSc, DACVP
    St. Jude Children's Research Hospital

    3:55-4:15 pm Attendee presentation
    4:15-5:00 pm

    Colorectal Cancer/IBD Models

    Piper Treuting, DVM, PhD, DACVP
    Seagen (Seattle Genetics) (acquired by Pfizer in 2023)

  5. Friday, September 13
    Advanced Methods in Pathology
    8:30-9:15 am

    Applying Image Analysis Methods in Pathology

     

    Kelli Boyd, DVM, PhD, DACVP
    Senior Director, Nonclinical Safety and Pathobiology, Gilead Sciences

    9:15-10:00 am

    The Histopathologist's Role in Spatial Multiomic Studies

     

    Kenneth Kim DVM, DACVP
    Director, Histopathology Core, La Jolla Institute for Immunology

    10:00-10:15 am Break
    10:15-11:00 am

    Basic Multiomic Bioinformatics for Histopathologists - Do I Really Have to Know This? 

     

    Kenneth Kim, DVM, DACVP
    La Jolla Institute for Immunology

    11:00 am-12:00 pm

    Introduction to QuPath Software

     

    Sara McArdle, PhD,
    La Jolla Institute for Immunology

    12:00-1:00 pm Lunch break (Lunch included with registration)
    1:00-2:45 pm

    Applications of QuPath Software

     

    Sara McArdle, PhD,
    La Jolla Institute for Immunology

    2:45-3:00 pm Break
    3:00-4:45 pm

    Choice of visit to one of the St. Jude Shared Resources, or hands-on training on the image analysis platform Halo

     

    Adam Smith, PhD
    Life Sciences Applications, Indica Laboratories

    4:45-5:00 pm

    Closing Remarks

     

    Laura Janke, DVM, PhD, DACVP
    St. Jude Children’s Research Hospital

 
 
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