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Explore our cutting edge research, world-class patient care, career opportunities and more.
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Developing clinical pathways to combat infections in immunocompromised pediatric patients
Infections pose a significant threat to patients undergoing therapy for cancer and other catastrophic diseases. Treatments for these conditions often leave patients with weakened immune systems, rendering them vulnerable to bacterial, fungal and viral infections. My research focuses on understanding the infections that complicate care for patients at St. Jude and developing better ways to manage, prevent and treat those infections.
My research aims to elucidate how infections — particularly antimicrobial-resistant infections — complicate the care of patients undergoing treatment for pediatric cancer and other catastrophic diseases and how to mitigate these threats. To better treat these infections, we must better understand the epidemiology of these pathogens. Once these infections are characterized, I work closely with my Infectious Diseases colleagues as well as my colleagues in the Departments of Chemical Biology & Therapeutics and Pharmacy & Pharmaceutical Sciences and use systematic reviews to identify the most appropriate treatment options for these infections and then modify them to suit the unique needs of our patient population at St. Jude. These modifications become clinical pathways — a standardized way to manage patients so that all our patients can be treated in the best way that suits our population.
A recent focus of my research is on antimicrobial resistance, which presents a significant problem in clinical practice. There was a time when antimicrobials were effective and readily available to treat patients with serious infections; however, due to myriad reasons, including overprescribing and noncompliance, resistance has become common. This leads to a small number of effective antimicrobials available, which may have more side effects than the traditional drugs we would use; in some cases, there may be infections we have no treatment for. We are elucidating the risk factors for infections caused by resistant bacteria, identifying best practices for treating these infections and testing new antimicrobials to combat this emerging threat to our patients.
Elisabeth Adderson, MD, MSc, is a Department of Infectious Diseases associate member. She graduated from the University of Alberta School of Medicine and pursued training in Pediatrics and Pediatric Infectious Diseases from Dalhousie University and Washington University School of Medicine. Adderson is board-certified in Pediatrics, with subspecialty certification in Pediatric Infectious Diseases. She earned her Master of Science in Clinical Trials from the London School of Hygiene and Tropical Medicine.
In addition to her clinical research work at St. Jude, Adderson has placed a strong emphasis on mentorship and training for physician-scientists. She is the Associate Designated Institutional Official for St. Jude Hematology/Oncology programs and associate director of the St. Jude Children’s Research Hospital/University of Tennessee Health Sciences Center Pediatric Infectious Diseases Fellowship Program; these programs provide training in clinical medicine and basic, clinical, and translational science research to physicians. Adderson has also developed training programs in Infections of Immunocompromised Children and Adolescents, Pediatric Infectious Diseases for Global Practitioners and Pediatric HIV medicine and has enthusiastically mentored postdoctoral fellows, graduate and undergraduate students. She is a faculty member in the St. Jude Graduate School of Biomedical Sciences, where she teaches in the Clinical Investigation Master’s program.
Elisabeth Adderson, MD, MSc
Associate Member, Department of Infectious Diseases
MS 320
St. Jude Children's Research Hospital