Facilitating translational research and the search for cures, one compound at a time.
The Compound Management (CM) Center is comprised of a team of scientists and biomedical engineers who curate the valuable St. Jude small molecule (also referred to as a compound) library, using state-of-the-art automation and electronic data management systems. The library has an active inventory of greater than 650,000 compounds stored in a sub-zero robotic environment. The library is continuously updated and accessed by researchers across campus, to aid in their search for new cures to pediatric catastrophic diseases.
The practice of compound management involves the acquisition, registration, quality control, storage, retrieval, formatting, and delivery of compounds to the researcher for biological screening and pre-clinical research. Every step in the process from acquisition to delivery is tracked via an industry-standard laboratory information management system (LIMS.) Effective and accurate CM procedures are vital to the accuracy of the researchers’ experiments and to the project’s success. Delivery of the correct compounds, at the correct concentration, in the correct format, all performed in a fast and efficient manner, is critical to attaining accurate scientific data.
We create an environment for acquiring molecules easier, so investigators can focus on the research. We know where to look and who provides the best samples. We also collaborate with other CBT centers to ensure their quality and integrity.
Shalandus Garrett, Senior Researcher
Julianne Bryan is a pioneer in the application of project management methodologies to scientific discovery environments. She began using and formalizing project management practices for lead/drug discovery while a bench scientist at Scriptgen Pharmaceuticals in 1997. Julie was instrumental in transforming a proprietary screening technology from theory to practice and ultimately became the HTS Group Leader, managing a team of 20+ scientists. She has been involved with high throughput screening and compound management since the mid-90’s.In 2005, Julie moved to Memphis from Boston, to create, implement, and direct a Project Management Office (PMO) for lead and tool discovery in the Department of Chemical Biology and Therapeutics (CBT) at St. Jude. She is a Project Management Institute certified Project Management Professional (PMP) and a Distinguished Toastmaster (DTM.) Julie earned a Bachelor of Arts in Biological Sciences from Mount Holyoke College.
I came into my degree, biomedical engineering, thinking I was going to go into product design, but CM has provided me the opportunity to try out new things. It has reframed my perspective on what a biomedical engineer can be, and I think it's impacted how I perceive myself and my career trajectory.
Andrew Williams, Compound Management Student
Julianne Bryan, PMP, Director
St. Jude Children Research Hospital