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Explore our cutting edge research, world-class patient care, career opportunities and more.
St. Jude Children's Research Hospital Home
- Fundraising
About the Department
Investigators in the Department of Tumor Cell Biology are driven to understand how oncogenes, tumor suppressors, and checkpoint monitors of cellular stress govern tumor initiation, progression, and responses to cancer therapy. Identifying key regulatory proteins, defining their mechanisms of action, and determining how they function within complex signaling networks continues to provide a better understanding of the fundamental processes controlling cell proliferation, apoptosis, cell migration, and metastasis. Emphasis is placed on mouse models of particular pediatric cancers, including medulloblastoma, atypical teratoid rhabdoid tumors, neuroblastoma, and acute lymphoblastic leukemia. All faculty members participate in interdepartmental Program Project Grants and basic science programs of the Comprehensive Cancer Center.
Our Faculty
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Chunliang Li, PhD
Associate Member, St. Jude Faculty
Chunliang Li, PhD
Associate Member, St. Jude Faculty
Affiliations
Research Interests
- Contribution of non-coding elements and dysregulated transcription in cancer
- Chromatin architecture
- Acute myeloid leukemia and acute lymphoblastic leukemia
- Development of novel leukemia strategies
Contact Information
Chunliang Li, PhD
Tumor Cell Biology
MS 350, Room D5006E
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Martine F. Roussel, PhD
Member, St. Jude Faculty
Member, Tumor Cell Biology
Endowed Chair in Molecular Oncogenesis
Professor, Department of Molecular Sciences, UT Memphis
Martine F. Roussel, PhD
Member, St. Jude Faculty
Member, Tumor Cell Biology
Endowed Chair in Molecular Oncogenesis
Professor, Department of Molecular Sciences, UT Memphis
Affiliations
Research Interests
- The tumor suppressor pathway Arf/Mdm2/p53 in cancer
- Positive and negative regulation in brain development and cancer
- Genes and microRNAs in brain tumors
- Development of mouse models of human brain cancers to conduct pre-clinical trials with novel targeted therapies
- G1 progression and G1/S control
- Role of the BMP-Atohnal signaling pathway in development and tumorigenesis
Contact Information
Martine F. Roussel, PhD
Tumor Cell Biology
MS 350, Room 5006C
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Charles J. Sherr, MD, PhD
Member, St. Jude Faculty
Chair, Tumor Cell Biology Department
Herrick Foundation Endowed Chair in Tumor Cell Biology
Charles J. Sherr, MD, PhD
Member, St. Jude Faculty
Chair, Tumor Cell Biology Department
Herrick Foundation Endowed Chair in Tumor Cell Biology
Affiliations
Research Interests
- Oncogenes and tumor suppressors
- Mechanics of cell division cycle control
- Perturbation of cell cycle regulators in cancer
Contact Information
Charles J. Sherr, MD, PhD
Tumor Cell Biology
MS 350, Room D5006D
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Join us
St. Jude investigators have the freedom to focus on making big discoveries, backed by extraordinary resources and support teams. We are always looking for highly motivated scientists and engineers with passion and talent to join us!
Contact us
Department of Tumor Cell Biology
MS350
St. Jude Children's Research Hospital
Memphis, TN, 38105-3678 USA GET DIRECTIONS