Investigators in the Department of Tumor Cell Biology are driven to understand how oncogenes, tumor suppressors, and checkpoint monitors of cellular stress govern tumor initiation, progression, and responses to cancer therapy. Identifying key regulatory proteins, defining their mechanisms of action, and determining how they function within complex signaling networks continues to provide a better understanding of the fundamental processes controlling cell proliferation, apoptosis, cell migration, and metastasis. Emphasis is placed on mouse models of particular pediatric cancers, including medulloblastoma, atypical teratoid rhabdoid tumors, neuroblastoma, and acute lymphoblastic leukemia. All faculty members participate in interdepartmental Program Project Grants and basic science programs of the Comprehensive Cancer Center.
Unraveling the molecular aspects of protein folding and the biological impact of folding failures.
Understanding structure-function relationships in complex biochemical systems at the single-molecule scale
Understanding the molecular basis of malignant pediatric brain tumors and developing preclinical pipelines to evaluate therapeutic approaches
Investigating mechanisms by which mitogens relay proliferative signals that affect progression through the mammalian cell division cycle.
St. Jude investigators have the freedom to focus on making big discoveries, backed by extraordinary resources and support teams. We are always looking for highly motivated scientists and engineers with passion and talent to join us!