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Models for Wilms tumor research
12/20/2019
Forty-five patient-derived xenografts capture the clinical and biological heterogeneity of Wilms tumor.
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Like a crystal ball, a blood test can predict when serious infections will strike
12/19/2019
Researchers at St. Jude showed that a new test predicted bloodstream infections up to three days before symptoms appeared.
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ALL risk genes give new understanding of leukemia biology
11/25/2019
Researchers find variant common in leukemia that afflicts children and a different leukemia that afflicts adults.
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Transporter activity depends on its cargo
11/13/2019
Scientists at St. Jude, Weill Cornell Medicine and Columbia University applied single-molecule imaging technologies to explain the activity of specific transporter proteins.
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Clinical trial lowers ALL relapse rate
10/28/2019
Results are in from a ten-year long clinical trial aimed at preventing relapse in pediatric patients with acute lymphoblastic leukemia.
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Understanding the control system for regulatory T cells
10/24/2019
MTORC1 may be more than just a molecular pathway. This enzyme may open up new avenues for treating autoimmune diseases and can boost cancer immunotherapy.
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Exercise may give the brain a boost
10/21/2019
A St. Jude study reveals more about the link between cancer survivors’ physical fitness and their thinking and learning skills.
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Pharmacogenetics of thiopurine and NUDT15 mutations presented at ASHG
10/18/2019
Researchers have uncovered a relationship between the gene NUDT15 and how thiopurine drugs function. These findings support the use of NUDT15 to guide thiopurine dose to limit treatment related toxicity.
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Study of telomere length and chronic health conditions presented at ASHG
10/16/2019
St. Jude researchers compared telomere length and age-dependent telomere attrition between childhood cancer survivors and adult control subjects.
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Do vitamins A and D help the flu vaccine work better? It depends.
10/08/2019
Vitamins A and D can impact how well some children respond to the flu vaccine.
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St. Jude will help lead national push to create more effective flu vaccines
09/30/2019
Flu is particularly dangerous for some people, including young cancer patients. Here’s the latest on how St. Jude scientists are working to protect them.
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Childhood cancer treatment can alter Leydig cell function
09/26/2019
Data from the St. Jude Lifetime Cohort Study reveals that current treatment for childhood cancer can affect testosterone production in men.
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Research reveals structural details of chaperones, critical molecules of the cell
09/20/2019
St. Jude scientists have uncovered a new discovery that reveals how chaperones manage protein folding – which could lead to finding ways to fight disease.
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Molecule offers focus for taming inflammation
09/12/2019
Chronic inflammation can be deadly. St. Jude researchers have identified a molecule that might lead to new ways to shut it down.
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How sweet it is: PeCanPIE serves up cancer variants
09/05/2019
Powerful cancer data portal gets an upgrade to identify the genetic culprit for inherited cancer and possibly other genetic diseases.
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Step aside Marie Kondo, the genome is the real organizational expert
09/04/2019
St. Jude researchers have uncovered the secrets of genome packaging revealed in the 3D genome.
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Monitoring infection in patients with compromised immune systems
09/03/2019
Digital polymarese chain reaction testing can correlate the amount of virus present in a sample with clinical systems.
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Taking a wider view reveals potential targets for rhabdoid tumors
08/27/2019
New study finds new rhabdoid tumor targets by identifying which targets these tumors need to survive.
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Reimagining β-thalassemia and its treatment
08/21/2019
Read the latest on a possible role for rapamycin treatment for b-thalassemia.
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Image captures ‘streamlined essence of what life entails’
08/19/2019
A St. Jude researcher may have found a possible answer to "one of the most interesting questions in science."
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Evaluating pediatric cancer through the lens of time
07/29/2019
New study accounts for years of life lost due to cancer. It’s the first time this metric has been used to analyze the childhood cancer burden globally.
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BRCA2 gene linked to risk of non-Hodgkin lymphoma
07/25/2019
A St. Jude study linked inherited mutations in the BRCA2 gene with a higher risk of non-Hodgkin lymphoma.
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Studying single cells to understand a type of pediatric brain tumor
07/24/2019
Scientists completed the most in-depth study of medulloblastoma subtypes by studying single cells to help shed light on how cells become cancerous.
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Learning from rare disorders
07/17/2019
Science Advances highlights St. Jude research into rare inherited Lysosomal disorders caused by mutations in the NEU1 gene.
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Too little or too much DUX4 is just right
07/11/2019
St. Jude researchers discover protein that may improve treatment for B-ALL in some patients. Learn more about how this gene’s expression impacts development.
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Scientists follow the data to a surprise
06/27/2019
Researchers surveyed the accumulation of toxic proteins in Alzheimer’s models, and discovered that a pathway nicknamed LANDO can limit the protein buildup.
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Leukemia mutations: sometimes less is more
06/26/2019
It’s true that adult tumors often have more mutations. Young ALL patients have fewer mutations, but the T cells identify more than two-thirds of them.
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Researchers discover key genetic trigger that compromises cancer immunotherapy
06/17/2019
T cell exhaustion has proven to be an obstacle for immunotherapy, and investigators hope their basic findings will result in techniques to prevent exhaustion.
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Study reveals function of cancer-linked MAGE genes
05/29/2019
The research shows that MAGE genes evolved to protect inherited DNA in men from stress, focusing on a subtype of MAGE genes called MAGE-A.
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Exploring how to get more out of vaccine protection
05/21/2019
Cell Host & Microbe study reveals the nearly 70 proteins the bacteria need to spread and set up shop (colonize) on someone new.
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Schedule changes improve treatment for acute lymphoblastic leukemia
05/20/2019
Scheduling delivery of the drug asparaginase with a discontinuous schedule of dexamethasone helps reduce bone damage when the two drugs were given together.
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Flu and strep team up to cause respiratory woes
05/20/2019
Researchers report for the first time that flu sticks to the surface of common respiratory bacteria.
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First St. Jude director and CEO honored as Giant of Cancer Care
05/10/2019
The Giants of Cancer Care recognition program honors those who advance the field of oncology through research or clinical care.
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Clues to help cancer survivors with hearing loss ace reading
05/02/2019
Research reveals that survivors with treatment-related severe hearing loss can benefit from personalized reading interventions to focus on reading skills.
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Researchers reveal key process that regulates cell division
04/30/2019
Read how fluctuations in the intrinsically disordered protein p27 play a key role in regulating cell division.
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Different immune cell implicated in lupus-related kidney disease
04/29/2019
This work shows for the first time that a type of immune cell called a patrolling monocyte plays a critical role in glomerulonephritis, inflammation of the kidneys
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Biological machinery of cell’s “executioner” yields secrets of its control
04/25/2019
Discovery of control signals for cell-killing necroptosis promises new treatment pathway for cancers and a broad array of other disorders.
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St. Jude gene therapy holds promise for treating several diseases, including SCID
04/17/2019
Out of the bubble: Newborns with SCID-X1, also known as "bubble boy" disease, have fully functional immune system for the first time after gene therapy. Learn more about the study.
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Mechanism revealed that dooms patients with Lou Gehrig’s disease
04/10/2019
Read about how the most common genetic cause of ALS disrupts cell function and how that might lead to new ways to diagnose and treat the disease
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Inherited gene variation may increase leukemia risk
04/01/2019
The scientists linked inherited variants of the gene USP7 with an increased risk of T-ALL. Changes in this gene are more common in individuals who are African American.
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Tracking the source of bone cancer mutations
04/01/2019
Read about efforts to improve cure rates for the bone cancer osteosarcoma by tracking how the chemo drug cisplatin may contribute to mutations.
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Genetic secrets yield treatment clues
03/29/2019
Genomic analysis reveals age-related subsets of acute erythroid leukemia.
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Finding a 'needle' in a 'haystack' just got easier
03/13/2019
Software helps to reduce error rates in next-generation sequencing data, expanding the clinical potential for the information.
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How one patient revealed a new route to melanoma
03/04/2019
Read latest on a mutation that drives the most common childhood melanoma plus evidence that patients who carry the alteration may respond to precision medicine.
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Radiation triples survival for a rare brain tumor
03/01/2019
Treatment success shown in ependymoma clinic trial open at more than 100 locations and with nearly 400 patients.
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Unraveling the connection between ancestry and cancer
02/21/2019
Scientists found variations in a fourth gene that is linked to a 50% increased ALL risk in Hispanic children. The risk was much lower for non-Hispanic children with the variation.
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Reducing alert fatigue
02/13/2019
A time-consuming issue for clinicians is assessing drug alerts in EHR systems. Researchers evaluated alerts and found ways to safely reduce alert overrides by 40 percent.
