Forty-five patient-derived xenografts capture the clinical and biological heterogeneity of Wilms tumor.
St. Jude showed that a new test predicted bloodstream infections up to three days before symptoms appeared.
Researchers find variant common in leukemia that afflicts children and a different leukemia that afflicts adults.
St. Jude, Weill Cornell Medicine and Columbia University applied single-molecule imaging technologies to explain the activity of specific transporter proteins.
Results are in from a ten-year long clinical trial aimed at preventing relapse in pediatric patients with acute lymphoblastic leukemia.
MTORC1 may be more than just a molecular pathway. This enzyme may open up new avenues for treating autoimmune diseases and can boost cancer immunotherapy.
St. Jude study reveals more about the link between cancer survivors’ physical fitness and their thinking and learning skills.
Researchers have uncovered a relationship between the gene NUDT15 and how thiopurine drugs function. These findings support the use of NUDT15 to guide thiopurine dose to limit treatment related toxicity.
St. Jude researchers compared telomere length and age-dependent telomere attrition between childhood cancer survivors and adult control subjects.
Vitamins A and D can impact how well some children respond to the flu vaccine.
Flu is particularly dangerous for some people, including young cancer patients. Here’s the latest on how
St. Jude scientists are working to protect them.
Data from the
St. Jude Lifetime Cohort Study reveals that current treatment for childhood cancer can affect testosterone production in men.
St. Jude scientists have uncovered a new discovery that reveals how chaperones manage protein folding – which could lead to finding ways to fight disease.
Chronic inflammation can be deadly.
St. Jude researchers have identified a molecule that might lead to new ways to shut it down.
Powerful cancer data portal gets an upgrade to identify the genetic culprit for inherited cancer and possibly other genetic diseases.
St. Jude researchers have uncovered the secrets of genome packaging revealed in the 3D genome.
Digital polymarese chain reaction testing can correlate the amount of virus present in a sample with clinical systems.
New study finds new rhabdoid tumor targets by identifying which targets these tumors need to survive.
Read the latest on a possible role for rapamycin treatment for b-thalassemia.
St. Jude researcher may have found a possible answer to "one of the most interesting questions in science."
New study accounts for years of life lost due to cancer. It’s the first time this metric has been used to analyze the childhood cancer burden globally.
St. Jude study linked inherited mutations in the BRCA2 gene with a higher risk of non-Hodgkin lymphoma.
Scientists completed the most in-depth study of medulloblastoma subtypes by studying single cells to help shed light on how cells become cancerous.
Science Advances highlights
St. Jude research into rare inherited Lysosomal disorders caused by mutations in the NEU1 gene.
St. Jude researchers discover protein that may improve treatment for B-ALL in some patients. Learn more about how this gene’s expression impacts development.
Researchers surveyed the accumulation of toxic proteins in Alzheimer’s models, and discovered that a pathway nicknamed LANDO can limit the protein buildup.
It’s true that adult tumors often have more mutations. Young ALL patients have fewer mutations, but the T cells identify more than two-thirds of them.
T cell exhaustion has proven to be an obstacle for immunotherapy, and investigators hope their basic findings will result in techniques to prevent exhaustion.
The research shows that MAGE genes evolved to protect inherited DNA in men from stress, focusing on a subtype of MAGE genes called MAGE-A.
Cell Host & Microbe study reveals the nearly 70 proteins the bacteria need to spread and set up shop (colonize) on someone new.
Scheduling delivery of the drug asparaginase with a discontinuous schedule of dexamethasone helps reduce bone damage when the two drugs were given together.
Researchers report for the first time that flu sticks to the surface of common respiratory bacteria.
The Giants of Cancer Care recognition program honors those who advance the field of oncology through research or clinical care.
Research reveals that survivors with treatment-related severe hearing loss can benefit from personalized reading interventions to focus on reading skills.
Read how fluctuations in the intrinsically disordered protein p27 play a key role in regulating cell division.
This work shows for the first time that a type of immune cell called a patrolling monocyte plays a critical role in glomerulonephritis, inflammation of the kidneys
Discovery of control signals for cell-killing necroptosis promises new treatment pathway for cancers and a broad array of other disorders.
Out of the bubble: Newborns with SCID-X1, also known as "bubble boy" disease, have fully functional immune system for the first time after gene therapy. Learn more about the study.
Read about how the most common genetic cause of ALS disrupts cell function and how that might lead to new ways to diagnose and treat the disease
The scientists linked inherited variants of the gene USP7 with an increased risk of T-ALL. Changes in this gene are more common in individuals who are African American.
Read about efforts to improve cure rates for the bone cancer osteosarcoma by tracking how the chemo drug cisplatin may contribute to mutations.
Genomic analysis reveals age-related subsets of acute erythroid leukemia.
Software helps to reduce error rates in next-generation sequencing data, expanding the clinical potential for the information.
Read latest on a mutation that drives the most common childhood melanoma plus evidence that patients who carry the alteration may respond to precision medicine.
Treatment success shown in ependymoma clinic trial open at more than 100 locations and with nearly 400 patients.
Scientists found variations in a fourth gene that is linked to a 50% increased ALL risk in Hispanic children. The risk was much lower for non-Hispanic children with the variation.
A time-consuming issue for clinicians is assessing drug alerts in EHR systems. Researchers evaluated alerts and found ways to safely reduce alert overrides by 40 percent.