Scientists from St. Jude Children’s Research Hospital will present research at the American Association for Cancer Research (AACR) annual meeting. The five-day international conference begins March 29 in Atlanta.
On Sunday, the Cancer Control and Survivorship Program at St. Jude will receive the 13th AACR Team Science Award during the meeting’s opening ceremony. The award recognizes innovative, interdisciplinary research that has advanced understanding or treatment of cancer. Read the Press Release.
St. Jude Cloud
St. Jude Cloud will showcase its growth since the data-sharing platform premiered at the 2018 AACR annual meeting. The platform now includes 10,000 sequenced whole genomes from pediatric cancer patients, survivors and others.
Visit our Booths
Genetic Predispositions to Childhood Leukemias: Implications for Pathogenesis and Screening
Friday, March 29
Educational Session ED32
Advances in Organ Site Research: Genetic Predisposition in Hematologic Malignancies
Monday, April 1
Educational Session AOS01
Science of Survivorship: The intersection of survivorship and aging
Monday, April 1
Georgia Ballroom 3 - Building C
8:00 a.m. - Noon
Acquisition of drug resistance mutations during chemotherapy treatment in pediatric acute lymphoblastic leukemia
Analysis of error profiles in deep next-generation sequencing data
1:00 - 5:00 p.m.
Increased prevalence of germline monoallelic RECQL4 mutations in children with cancer
USP7 heterozygous loss-of-function affects T-cell differentiation in pediatric T-ALL
Visualize 10,000 whole-genomes from pediatric cancer patients on St. Jude Cloud
Single-cell characterization and lineage tracking of recurrent pediatric rhabdomyosarcoma
8:00 a.m. - Noon
Modeling the vascular sarcoma spectrum with genetically engineered mice
Whole-genome sequencing of childhood cancer survivors treated with cranial radiation therapy identifies 5p15.33 locus for stroke: A report from the St. Jude Lifetime Cohort (SJLIFE) study
Researchers at St. Jude have identified a chromosomal region associated with an increased risk of stroke among adult survivors of childhood cancer treated with cranial radiation therapy. This investigation draws on whole genome sequencing data gathered through the St. Jude Lifetime Cohort (SJLIFE) study. The investigators found a significant association between variants on a chromosomal region called 5p15.33, dose level of cranial radiation therapy and risk of stroke. These results suggest that testing for variants of 5p15.33 may be useful for identifying patients who, when treated with cranial radiation therapy, will be at a high-risk of stroke as adults. “This is one of the first studies to evaluate the genomic underpinnings of stroke in such a robust cohort,” said Yadav Sapkota, PhD, of the St. Jude Department of Epidemiology and Cancer Control.
Acute depletion of CTCF directly affects MYC regulation through loss of enhance-promoter looping
Genomic instability and the development of high-grade glioma
Representatives from St. Jude Cloud will be available to answer questions in the Exhibit Hall at Booth #4136. Learn about the unique resources and data available for researchers, including GenomePaint. Attend a demonstration:
Making Discoveries on St. Jude Cloud
Scott Newman, PhD
Monday, April 1 at 10:30 – 11:30 a.m.
Tuesday, April 2 at 2:00 – 3:00 p.m.
Announcing and Investigating GenomePaint
Alex Gout, PhD
Monday, April 1 at 2:00 – 3:00 p.m.
Tuesday, April 2 at 10:30 – 11:30 a.m.
Saturday, March 30
9:00 a.m. – 3:00 p.m.
Representatives from St. Jude Children’s Research Hospital will be available to answer questions on positions for post-docs, researchers, clinical fellows and more.