Research

Learn about published research as well as leading-edge basic and translational research initiatives from St. Jude laboratories.

CRISPR kickstarts combination drug discovery for neuroblastoma

Alex Generous, PhD

A CRISPR screen reveals a potential combination therapy for relapsed neuroblastoma.

Finding the big-TIME players holding back CAR T–cell therapy for high-grade gliomas

Alex Generous, PhD

Explore how tumor-associated macrophages shape CAR T-cell therapy efficacy in high-grade gliomas.

Ribosome production presents a new therapeutic opportunity against Wilms tumor

Alex Generous, PhD

Discover how disruption ribosomes creation provides promise for “undruggable” cancers.

Just like the real thing: Synthetic gene expression regulators demonstrate success

Brian O'Flynn, PhD

See how Aseem Ansari's SynGRs target BET proteins, offering potential for treating diseases like Friedreich’s ataxia and advancing BET domain understanding

St. Jude Research Collaboratives program reaches across institutional boundaries to multiply impact

Jessica Gullett-Rubino, PhD

Learn more about how the St. Jude Research Collaboratives Program is driving scientific breakthroughs.

Consortium on leukemia in children with Down syndrome offers energy and optimism

Brian O'Flynn, PhD

Leukemia in children with Down syndrome addressed at St. Jude as international consortium meets

Shared Resources Spotlight: Biostatistics Shared Resource

Elizabeth Casolo

Meet the investigators in the Biostatistics Shared Resource to learn how this under-recognized field is a critical component of successful research.

Preventing neurodevelopmental disorders through genetic compensation

Brian O'Flynn, PhD

See how a gene family is implicated in the cause and rescue of neurodegenerative disease

Electrical engineering sparks discovery in how human nuclear receptors bind to DNA

Brian O'Flynn, PhD

See how nuclear receptors selectively bind to DNA.

Shared Resources Spotlight: Center for Advanced Genome Engineering

Elizabeth Casolo

Research from the Center for Applied Genome Engineering plays a pivotal role in discovery.