Progress Pulse

Short summaries of scientific findings from across the St. Jude research enterprise.

Strategies for communicating with honesty and hope in uncertain prognostic situations

Discover how patient- and caregiver-derived insights from the RIGHTime study are being used to characterize best practices in patient-centered prognostic conversations.

Study links changes in the SMARCAL1 gene to increased risk for bone cancer

Researchers at St. Jude studying DNA damage repair genes have discovered a predisposition gene for osteosarcoma

Machine learning reveals sources of accelerated brain aging in childhood cancer survivors

Learn how identifying correlates of accelerated aging may help prevent neurocognitive decline.

Accelerating molecular glue discovery with a direct-to-biology approach

See how mass spectrometry can reduce lead discovery from months to hours.

Norepinephrine ‘reset switch’ affects decision-making

See how norepinephrine aids with brain remapping

Understanding adaptation and implementation challenges in pediatric ALL

Learn about the challenges of adapting and implementing pediatric acute lymphoblastic leukemia treatments in low- and middle-income countries.

Sequencing large-scale changes in DNA to detect cancer earlier

Discover how St. Jude scientists improved detection of large structural changes in DNA to identify cancer cells.

Expedited and accurate detection of targeted gene fusions with St. Jude Fuzzion2

Learn about Fuzzion2, the fuzzy pattern-matching program developed to detect targeted gene fusions with speed and accuracy.

Therapy to reduce the risk of relapse after transplantation does not increase the risk of graft-versus-host disease

A retrospective study finds donor lymphocyte infusions after transplant can lower relapse risk without increasing the risk of graft-versus-host disease.

Reducing the risk of cerebellar mutism syndrome through surgical guidelines

Read how surgeons aim to reduce posterior fossa syndrome risk