Researchers at St. Jude have identified compounds that target intrinsically disordered proteins (IDPs). They inhibit disordered proteins by sequestration them in soluble oligomers. Inhibition of a specific IDP, p27Kip1 (p27 hereafter), was demonstrated and may represent a general mechanism for inhibition of IDPs associated with human disease.
Small molecules were identified that bind to p27 and cause it to be sequestered within soluble oligomers, altering its cell cycle regulatory function. Potential applications include inhibiting the function of p27 in the cells of the inner ear of hearing damaged individuals with the potential to enable hearing cell regeneration; and/or inhibiting interactions between p27 and RhoA in certain breast cancers.
Intrinsically disordered protein (IDP), p27Kip1, p27, small molecules, compounds, soluble oligomers, inner ear, hearing damage, hearing cell regeneration, breast cancers.Intrinsically disordered protein (IDP), p27Kip1, p27, small molecules, compounds, soluble oligomers, inner ear, hearing damage, hearing cell regeneration, breast cancers.
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