Description
Methods are provided for modulating the activity of p53 tumor suppressor protein by affecting p53 translational regulation. The methods involve affecting the function of a p53 5’-untranslated region (5’UTR), including its interaction with proteins such as Ribosomal Protein L26 (RPL26), nucleolin, and p53. Use of RPL26 siRNA to downregulate p53 induction is shown. These methods can be developed for treatment of cancer, neurodegenerative disorders and minimizing the negative effects of cellular stresses.
Keywords
p53, nucleolin, RPL26
Granted Patents or Published Applications
US Publication No. 2009/0149377
Related Scientific References
Chen, J. et al., “Interactions of nucleolin and ribosomal protein L26 (RPL26) in the translational control of human p53”, J. Biol. Chem. (Epub. Mar. 20, 2012);
Takagi, M. et al., “Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin”, Cell 123: 49-63 (Oct. 6, 2005).
Licensing Opportunities
We are currently seeking licensing opportunities in all fields for the development of this technology. Contact: chad.riggs@stjude.org
Related Links
Technologies
- Activation of Prodrugs by Carboxylesterase (SJ-98-0001)
- Anti-GD2-BB-zeta Chimeric Receptor for Treating GD2+ Malignancies (SJ-13-0035)
- Association of Neuraminidase Regulated Exocytosis with Cancer Metastasis (SJ-11-0012)
- BCRP/ABCG2 as Stem Cell Marker (SJ-97-0016)
- Development and Optimization of a Serotype-Independent Method of Adeno-Associated Virus (AAV) Harvest and Purification (SJ-16-0036)
- DNA Methylation Profile and Biomarkers for identifying functional T-cells (SJ-17-0002)
- Gene Therapy for XSCID (SJ-16-0006)
- Hybrid Compounds to treat Gastrointestinal Infections (SJ-14-0019/UTA 14-01)
- Improved Method to Produce Proteins to Treat Lysosomal Storage Disorders (SJ-01-0020)
- iNKT Cell Expansion Protocol (SJ-12-0033)
- Method for Enhancing Recombinant Antibody Production (SJ-08-0032)
- Minimized Liver Specific Promoter for Improved Gene Expression in Gene Therapy Vectors (SJ-04-0024)
- p53 Inhibitory Oligonucloeotides (SJ-09-0015)
- Rapid Cloning of T Cell Receptors (SJ-16-0001)
- RIPK3 Fusion Protein for Treating Cancer and Autoimmunity (SJ-12-0036)
- Use of IL35 to convert T-cells to Regulatory T-cells (SJ-09-0024)
Contact the Office of Technology Licensing (Phone: 901-595-2342, Fax: 901-595-3148) for more information.