The Childhood Solid Tumor Network (CSTN) offers the world's largest and most comprehensive collection of scientific resources for researchers studying pediatric solid tumors and related biology.

By freely sharing unique tools with no obligation to collaborate, we aim to promote global discovery and new treatments for pediatric patients with poorly understood and difficult-to-treat solid tumors.

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    Available Resources

    View lists of our orthopedic patient-derived xenografts, as well as information about data, GEMMs and other available resources.

  • Dyer Pappo
    Frequently Asked Questions

    FAQs about the process for requesting and receiving solid tumor research resources from the Childhood Solid Tumor Network.


About the Childhood Solid Tumor Network

Childhood solid tumors are often difficult to study and treat because they are rare and originate in the complex biological context of developing organs. CSTN was established to disseminate resources and data that have been developed at St. Jude Children’s Research Hospital, with the aim of stimulating basic research and speeding translation to the clinic.

The effort was launched in 2013 by Howard Hughes Medical Institute investigator Michael Dyer, PhD, of St. Jude Developmental Neurobiology, and Alberto Pappo, MD, of St. Jude Oncology.

For more information, contact us: CSTN@stjude.org

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CSTN request metrics

Last updated June 2021

Total Requests

578

Total Vials Sent Out

1,605

Principal Investigators

230

Institutions

107

Countries

16


References

Read about our new method to produce orthotopic patient-derived xenografts. All O-PDX models and associated data are available. Please cite this reference in publications resulting from use of CSTN resources:

Stewart E, Federico S, Chen X, et al. Orthotopic patient-derived xenografts of paediatric solid tumoursNature 549(7670):96-100, 2017.

Other research articles


Lessons from the Sandbox
Read more about CSTN in the Autumn 2015 edition of Promise.

Related Topics
The Childhood Solid Tumor Network repository of PDXs has been invaluable to studying rare cancers, including rhabdomyosarcoma, a devastating cancer of muscle. The resource is open-access, free and comprises a large collection of well-annotated pediatric samples.

David M. Langenau, Ph.D. 
Associate Professor, Pathology, Harvard Medical School 
Assistant Molecular Pathologist, Molecular Pathology, Massachusetts General Hospital