Childhood solid tumors are often difficult to study and treat because they are rare and originate in the complex biological context of developing organs. CSTN was established to disseminate resources and data that have been developed at St. Jude Children’s Research Hospital, with the aim of stimulating basic research and speeding translation to the clinic.

CSTN request metrics

Last updated November 2022

Total Requests
655


Total Vials Sent Out
(>1900 samples)


Principal Investigators
275


Institutions
123


Countries
17

  • Woman in white coat and lab gloves looking into microscope
    Available Resources

    View lists of our orthopedic patient-derived xenografts, as well as information about data, GEMMs and other available resources.

  • Dyer Pappo
    Frequently Asked Questions

    FAQs about the process for requesting and receiving solid tumor research resources from the Childhood Solid Tumor Network.

References

Read about our new method to produce orthotopic patient-derived xenografts. All O-PDX models and associated data are available. Please cite this reference in publications resulting from use of CSTN resources:

Stewart E, Federico S, Chen X, et al. Orthotopic patient-derived xenografts of paediatric solid tumoursNature 549(7670):96-100, 2017.

Other research articles


Related Topics

"The Childhood Solid Tumor Network repository of PDXs has been invaluable to studying rare cancers, including rhabdomyosarcoma, a devastating cancer of muscle. The resource is open-access, free and comprises a large collection of well-annotated pediatric samples."

David M. Langenau, Ph.D. 
Associate Professor, Pathology, Harvard Medical School 
Assistant Molecular Pathologist, Molecular Pathology, Massachusetts General Hospital

About the Childhood Solid Tumor Network

The Childhood Solid Tumor Network was launched in 2013 by Howard Hughes Medical Institute investigator Michael Dyer, PhD, of St. Jude Developmental Neurobiology, and Alberto Pappo, MD, of St. Jude Oncology.

For more information, contact us: CSTN@stjude.org

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