The Center for Advanced Genome Engineering (CAGE) provides expertise and infrastructure for St. Jude investigators to educate, assist, expedite and perform established and emerging genome engineering technologies, including the CRISPR-Cas9 technology. The CAGE has 3 main objectives:
The CAGE is a world-class genome editing facility with the mission to provide low cost, expeditious, and collaborative genome engineering services to St. Jude investigators. The CAGE boasts the expertise and infrastructure to educate, assist, expedite, and perform established and emerging technologies, including CRISPR/Cas9.
The genome engineering field is rapidly evolving. Accordingly, the CAGE spends time identifying, testing, and evaluating the latest genome editing tools, technologies, and applications. CAGE has worked with over 75 St. Jude investigators across 15 departments. Since inception in 2017, CAGE scientists have enabled, collaborated on, or published over 50 research papers in high quality journals including Cell, Nature, Nature Communications, Nature Genetics, and Nature Neuroscience. Additionally, team members have been collaborating authors on 29 publications in high quality journals.
“Before I was even on pay-roll I started developing CRISPR lines…and by the time I landed in January, those lines were in a freezer and [CAGE] was saying, ‘OK, what’s next?’ No other place is going to afford you that.”
Andrew Kodani, Assistant Member
Technology and advanced equipment