About CAB

The Center for Applied Bioinformatics (CAB) was established in 2019 with a mission to provide centralized genomic and bioinformatic analytic services for investigators at St. Jude Children's Research Hospital. The CAB is composed of research scientists and software engineers of diverse background and expertise, covering the areas of genomics, genetics, transcriptomics and epigenetics.

The key responsibilities of the CAB include:

  • Consult with St. Jude investigators on optimal experimental design for bioinformatics analyses
  • Develop state-of-art, open-access computational pipelines to address the most needed bioinformatics analyses in the institution
  • Provide standard and customized bioinformatics analyses to St. Jude investigators
  • Train students, postdoctoral fellows and staff scientists in standard bioinformatics analyses using pipelines deployed either in-house or by public web applications and software
  • Maintain the common reference annotation and datasets shared across the institution

The CAB strives to deliver high-quality results in a timely manner and emphasizes applied and expedient genetic and bioinformatics analyses for St. Jude research laboratories. It advocates a culture of open science and promotes a highly collaborative environment for joint computational tool development across various computational groups within the institution to support the mission of St. Jude and the research efforts of St. Jude investigators. 

Collaborative Teams

  • Bioinformatics DevOps - development of open access pipelines, databases and web applications to track project and data from St. Jude investigators running through CAB pipelines
  • Transcriptomics - quantification and dynamics of various RNA molecules in transcriptomic assays, at bulk or single cell RNA levels
  • Epigenetics - how various epigenetic modifications regulate RNA expression, including DNA methylation, chromatin opening, transcription factor binding, histone modification and chromatin-chromatin interactions
  • Genomics - germline and somatic genome variations, comparative and evolutionary genomics, viral genomics, and meta-genomics
  • Genetics - association of inherited or acquired genetic variations with clinical or phenotypic traits in human or model organism studies

Leadership

  • Gang Wu, PhD

    Director, CAB

    Faculty Bio

  • Yiping Fan, PhD

    Associate Director, CAB

    Group lead: Transcriptomics

  • Beisi Xu, PhD

    Group Lead: Epigenetics

  • Evadnie Rampersaud, PhD

    Group Lead: Genetics

  • Ti-Cheng Chang, PhD

    Group Lead: Genomics

  • Yawei Hui, PhD

    Group Lead: DevOps