OVERVIEW

The CAB is an institutional shared resource, with the mission to provide state of the art bioinformatics services to St. Jude investigators. We maintain the highest level of scientific rigor by carefully vetting and documenting all bioinformatics methods and pipelines. The CAB consults with investigators on optimal experimental design for informatics analysis, develops state-of-the-art, open-access computational pipelines, and trains St. Jude investigators at all levels in standard analyses. 

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IMPACT

CAB believes that “Discovery Leads to Cures” and advocates an open science culture to help cultivate a highly collaborative environment for scientific research. They are credited with contribution on over 150 peer-reviewed publications from investigators across St. Jude and one of the most frequently identified essential resources. CAB is tightly integrated with the Hartwell Center for Biotechnology, providing uniform, automated data-mapping and storage to facilitate downstream analysis. CAB maintains the common reference annotation and datasets shared across the institution. All methods developed by CAB are shared with the international bioinformatics community

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The CAB is working FANTASTIC. We are really benefiting and value all the interactions…The collaboration and expertise has really been superb.

Mark Hatley, Associate Member


Collaborative Team

  • Bioinformatics DevOps: Focuses on the development of open access pipelines, databases and web applications to track project and data from St. Jude investigators running through CAB pipelines.
  • Transcriptomics Group: Focuses on the quantification and dynamics of various RNA molecules in the transcriptomic assays, at both bulk or single cell RNA levels
  • Epigenetics Group: Focuses on how various epigenetic modifications regulate RNA expression, including DNA methylation, chromatin opening, transcription factor binding, histone modification and chromatin-chromatin interactions.
  • Genomics Group: Focuses on germline and somatic genome variations, comparative and evolutionary genomics, viral genomics, and meta-genomics
  • Genetics Group: Focuses on the association of inherited or acquired genetic variations with clinical or phenotypic traits in human or other model organism studies

Services

  • Analysis: provide automated, routine and customized bioinformatics analyses
  • Consultation: provide consultation to optimize experimental design
  • Sharing: develop and validate state of the art open access pipelines and methods
  • Training: provide hands on training and resources to St. Jude employees
  • Data Management: Partner with informatics services to optimize data storage and computing resources
  • Reference: maintain reference datasets relevant to research at St. Jude

CAB by the numbers: 

5

functional groups

>1000

analyses requested annually

73

collaborative partnerships

70+ 

analyses pipelines

Director

Geoffrey Neale

Gang Wu, PhD

Director, CAB
Assistant Member, St. Jude Faculty
gang.wu@stude.org

BIOGRAPHY >