The PKSR facilitates and centralizes high-quality competitively funded peer-reviewed clinical pharmacokinetic/pharmacodynamic research in both clinical and pre-clinical models at St. Jude.
The Pharmacokinetics Shared Resource’s objectives are to facilitate appropriate pharmacokinetic study design; the efficient and proper collection and handling of biological samples for clinical pharmacokinetic studies; development or implementation of bioanalytical methods and quality control of sensitive and specific analyses of those samples for anticancer drugs, their metabolites, or other relevant pharmacologic indices; and biomedical modeling of pharmacokinetic and pharmacodynamic data.
The PKSR facilitates and centralizes high-quality competitively funded peer-reviewed clinical pharmacokinetic/pharmacodynamic research in both clinical and pre-clinical models at St. Jude. Working with investigators and clinicians across the institution, the PKSR has been acknowledged on over 180 peer-reviewed publications in the past 10 years for intellectual and technical contributions.
As the PI of complex clinical trials, such as SJDAWN and SJMB12, I recognize the importance pharmacokinetic studies play in determining if the medicine is getting to our patient’s cancer in appropriate concentrations. Having the PKSR, here at St Jude, means that not only do we get incredible in-house expertise to measure drug concentrations in our patients but that we also get state-of-the art sample receipt, processing, storage, and distribution whenever needed. This is an essential resource to support our trials and, most importantly, to help improve therapy.
Dr. Giles Robinson, Associate Member
Functions and usage