The CTP facilitates and centralizes high-quality competitively funded peer-reviewed clinical pharmacokinetic/pharmacodynamic research in both clinical and pre-clinical models at St. Jude.
The CTP facilitates high-quality, competitively funded, peer-reviewed pharmacokinetic/pharmacodynamic translational research in clinical protocols. Its key functions include:
The CTP resources have been and will continue to expand research horizons and funding by providing outstanding expertise in conducting pharmacokinetic and pharmacodynamic studies, developing novel biomedical models, and providing the highest quality of data while performing these studies in a cost-effective manner.
As the PI of complex clinical trials, such as SJDAWN and SJMB12, I recognize the importance pharmacokinetic studies play in determining if the medicine is getting to our patient’s cancer in appropriate concentrations. Having the CTP, here at St Jude, means that not only do we get incredible in-house expertise to measure drug concentrations in our patients but that we also get state-of-the art sample receipt, processing, storage, and distribution whenever needed. This is an essential resource to support our trials and, most importantly, to help improve therapy.
Dr. Giles Robinson, Associate Member
Major instrumentation includes:
The CTP has access to other Pharmaceutical Sciences division equipment, including:
Modeling and simulation activities use both computer workstations and the St. Jude supercomputing cloud.
Members access the CTP by requesting a consultation through the SRM2 portal. All clinical protocols will go through the CTP for Functions 1 and 2 (protocol implementation and sample acquisition) if they include PK/PD studies and access to analytical assay services (Functions 3 and 4). Study design/biomedical modeling (Function 5) is via discussion between investigators and CTP.
The Center for Translational Pharmacology (CTP) is located on the fifth floor of the Chili's Care Center (CCC), occupying 1,200 sq ft of space, and is integrated within the Division of Pharmaceutical Sciences, also located on the fifth floor of the CCC.