St. Jude Reference #SJ-20-0032
Researchers at St. Jude demonstrated that a MyD88.CD40 costimulatory chimeric receptor improved CAR T cell function. They believed MyD88 costimulation should be directly linked to T cell activation or triggered by a molecule that normally inhibits T cell function, so they designed two prototype receptors: i) an scfv-based MyD88 receptor that binds to IL-13 (IL13-MyD88) as an example of a MyD88 receptor that is linked to T-cell activation, and ii) a PD1-MyD88 receptor that binds to PDL1, a molecule that is expressed on the cell surface of tumor cells and inhibits T cell function.
The researchers developed and demonstrated with two examples that expression of chimeric MyD88 receptor in CAR T cells dramatically increase their antitumor activity. The findings apply broadly to CAR T cell therapies and other adoptive immune cell therapies. These Chimeric MyD88 receptors have the potential to improve the anti-tumor activity of cell therapies for a broad range of malignancies that are currently being developed.
We are seeking a partner to commercialize these costimulatory adoptive cell therapies with immune cells including CAR T cells, abTCR T cells, gdT cells, NKT cells, NK cells, and macrophages.
Immunotherapy, Biologics, MyD88, costimulatory chimeric receptor, IL-13, PD1-MyD88, PDL1, abTCR T cells, gdT cells, NKT cells, NK cells, and macrophages.
Granted patents or published applications
Pending international application published as WO 2021/211663
Related scientific references
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