Small molecules that can be used for targeted protein degradation of GSPT1/IKZF1 (SJ-21-0045)

St. Jude Reference #SJ-21-0045

Researchers at St. Jude created small molecules that target protein degradation of GSPT1/IKZF1 for the treatment of cancer (hematological malignancies, solid tumors). These compounds indicate greater potency for degradation over existing small molecules.

diagram of a compound


small molecule, drug, PROTAC. targeted protein degradation, CK1alpha, hematological cancer, solid tumor.

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Application filed, available under confidentiality

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