Chemotherapy can lead children to develop secondary cancers that have poor prognoses. St. Jude scientists are studying the genomics of a type of treatment-related blood cancer.
Results showed problems in cellular pathways and genes that are often altered in cancer. There was also very high transcription factor expression in some cases.
The research used tools developed at St. Jude. SequencErr finds instrument-caused errors. CleanDeepSeq can tell the difference between mutations and sequencing errors. The scientists tracked mutations two years before a treatment-related cancer developed.
A report on this work appeared in Nature Communications.