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Bringing Chemistry to Medicine Symposium


Held Thursday, July 22, 2021: Transcription Therapy
Held Friday, July 23, 2021: Frontiers in Chemical Biology

View Video Archive

 
 

The Bringing Chemistry to Medicine symposium featured thought leaders at the interface of chemical and biomedical sciences, working in areas spanning therapeutic regulation of transcription and chromatin, computational biology, and chemical biology. This year’s annual symposium featured two themes: Transcription Therapy (Thursday, July 22) and Frontiers in Chemical Biology (Friday, July 23).

This virtual symposium, hosted by the St. Jude Department of Chemical Biology and Therapeutics and the St. Jude Comprehensive Cancer Center, is a component of the institution’s strategic objective to establish a global hub focused on the emerging field of transcription-targeted therapeutics.

To enable broad participation and interaction among trainees and scientists around the world, registration was free.

 
 
 

Speakers

 
Madan Babu portrait

M. Madan Babu

St. Jude Children's Research Hospital

 
Suzanne Baker portrait

Suzanne J. Baker

St. Jude Children's Research Hospital

 
Jay Bradner portrait

James E. Bradner

Novartis Institutes for Biomedical Research

 
Andrea Califano portrait

Andrea Califano

Columbia University

 
Francesca Ciccarelli portrait

Francesca Ciccarelli

The Francis Crick Institute

 
Patrick Cramer portrait

Patrick Cramer

Max Planck Institute

 
Craig Crews portrait

Craig Crews

Yale University

 
Pedro R. Cutillas portrait

Pedro R. Cutillas

Cancer Research UK Barts Center

 
Cigall Kadoch portrait

Cigall Kadoch

Dana-Farber Cancer Institute, Harvard Medical School, and the Broad Institute of MIT and Harvard

 
William G. Kaelin portrait

William G. Kaelin, Jr

Dana-Farber Cancer Institute

 
Mitch Lazar portrait

Mitch Lazar

University of Pennsylvania

 
Jonathan Licht portrait

Jonathan Licht

University of Florida Health Cancer Center

 
Craig W. Lindsley portrait

Craig W. Lindsley

Vanderbilt University

 
Debora S. Marks portrait

Debora S. Marks

Broad Institute of MIT and Harvard, Harvard Medical School 

 
Marvin J. Miller portrait

Marvin J. Miller

University of Notre Dame

 
Anjana Rao portrait

Anjana Rao

La Jolla Institute for Immunology

 
Tobin Sosnick portrait

Tobin Sosnick

The University of Chicago

 
Professor Dame Janet Thornton portrait

Janet Thornton

The European Bioinformatics Institute

 
 

Agenda

Transcription Therapy logo

Held Thursday, July 22, 2021: Transcription Therapy

All times are in Central Time: 9 am CT

Time (Central) Presentation
9:00 - 9:15 am Opening Remarks
Watch Video
9:15 - 9:45 am Histone Mutations and Disrupted Development in Pediatric High-Grade Glioma
Suzanne J. Baker, PhD
Introduction by: Jamy C. Peng, PhD
Watch Video
9:45 - 10:15 am Recent Insights into Chromatin Transcription
Patrick Cramer, PhD
Introduction by: Mario Halic, PhD, and Silvija Bilokapic, PhD
Watch Video
10:15 - 10:30 am Break
10:30 - 11:00 am NSD2 in Lymphoid Malignancy
Jonathan D. Licht, MD
Introduction by: John D. Crispino, PhD, MBA
Watch Video
11:00 - 11:30 am Structure and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Human Cancer
Cigall Kidoch, PhD
Introduction by: Hai Dao, PhD
Watch Video
11:30 am - 12:00 pm Session Panel
Moderated by: Charles W.M. Roberts, MD, PhD
12:00 - 12:30 pm Lunch
12:30 - 1:00 pm Chemical Control of Gene Expression
James E. Bradner, MD
Introduction by: Adam D. Durbin, MD, PhD
Watch Video
1:00 - 1:15 pm Discussion
Moderated by: Aseem Ansari, PhD
1:15 - 1:45 pm Three Possible Paths to Targeting Undruggable Transcription Factors
William G. Kaelin, Jr., MD
Introduction by: Anand Patel, MD, PhD
Watch Video
1:45 - 2:15 pm Elucidation and Pharmacologic Targeting of Single Cell State Maintenance Mechanisms
Andrea Califano, PhD
Introduction by: Jiyang Yu, PhD
2:15 - 2:30 pm Break
2:30 - 3:00 pm Transcriptional Networks in Tumour-Infiltrating T Cells
Anjana Rao, PhD
Introduction by: Benjamin A. Youngblood, PhD
Watch Video
3:00 - 3:30 pm Personalization of Transcriptional Therapy With Drugs Targeting Nuclear Receptors
Mitchell A. Lazar, MD, PhD
Introduction by: Daniel Savic, PhD
Watch Video
3:30 - 4:00 pm Session Panel
Moderated by: Aseem Ansari, PhD
4:00 - 4:15 pm Closing Remarks
 
Chemical Biology and Therapeutics Symposium logo

Held Friday, July 23, 2021: Frontiers in Chemical Biology

All times are in Central Time: 9 am CT

Time (Central) Presentation
9:00 - 9:15 am Opening Remarks
9:15 - 9:45 am Rationalising Anti-Cancer Drug Responses Using Proteomics and Machine Learning: Towards Next Generation Precision Medicine
Pedro R. Cutillas, PhD
Introduction by: Tommaso Cupido, PhD
Watch Video
9:45 - 10:15 am Predictors of response to cancer immunotherapy: beyond Tumour Mutational Burden
Francesca Ciccarelli, PhD
Introduction by: Tommaso Cupido, PhD
Watch Video
10:15 - 10:30 am Break
10:30 - 11:00 am Using Response Surface Models to Analyze Drug Combinations
Anang A. Shelat, PhD
Introduction by: Tommaso Cupido, PhD
Watch Video
11:00 - 11:30 am Prediction of a Protein’s Free Energy Surface with Validation Using Hydrogen/Deuterium Exchange
Tobin R. Sosnick, PhD
Introduction by: Marcus Fischer, PhD
Watch Video
11:30 - 11:45 am Break
11:45 am - 12:15 pm Computational Enzymology: The Structure, Function and Evolution of Enzymes
Professor Dame Janet Thornton
Introduction by: Marcus Fischer, PhD
Watch Video
12:15 - 12:45 pm Variation in GPCR Signalling : Implications for Drug Discovery
M. Madan Babu, PhD, FRSC
Introduction by: Marcus Fischer, PhD
Watch Video
12:45 - 1:15 pm Session Panel
Moderated by Anang Shelat, PhD
1:15 - 1:45 pm Lunch
1:45 - 2:15 pm Discovery and Development of GPCR Allosteric Ligands: From Concept to Clinic
Craig W. Lindsley, PhD
Introduction by: Taosheng Chen, PhD, PMP
Watch Video
2:15 - 2:45 pm Design, Syntheses and Studies of New Antibiotics
Marvin J. Miller, PhD
Introduction by: Stephanie M. Reeve, PhD
Watch Video
2:45 - 3:00 pm Break
3:00 - 3:30 pm PROTAC-mediated Protein Degradation: A New Therapeutic Modality
Craig M. Crews, PhD
Introduction by: Zoran Rankovic, PhD
3:30 -4:00 pm Session Panel
Moderated by Richard Lee, PhD and Zoran Rankovic, PhD
4:00 - 4:15 pm Closing Remarks

Watch our Archived Lectures

In 2020 and 2021, St. Jude hosted exciting two-day events focused on Transcription Therapy and Chemical Biology and Therapeutics.

Visit our video archive link

Transcription Therapy at St. Jude

Over decades of research, scientists in the St. Jude Comprehensive Cancer Center and others have discovered that several pediatric cancers emerge due to disruption in chromatin and epigenetic states and dysfunctional transcriptional regulation. While gene regulation in general has long been considered “undruggable,” scientists in the St. Jude Department of Chemical Biology & Therapeutics (CBT) have created synthetic gene regulators and are devising new chemical approaches to inhibit or degrade malfunctioning components of chromatin and gene regulatory machineries. This work builds on the history of St. Jude as a pioneer in the therapeutic use of small molecules targeting gene regulation, most notably the application of glucocorticoid receptor agonists into chemotherapy regimens for pediatric patients with acute lymphoblastic lymphoma (ALL). The drugging of this transcription factor helped to dramatically increase overall survival rates for newly diagnosed ALL to 94% at St. Jude.

Learn more about transcription therapy at St. Jude    Learn more