About the Zhang Lab

We develop innovative analytical and visualization software tools to advance genomic analysis that enables finding cures for pediatric cancer and other diseases. We are committed to sharing data and software tools with the broad biomedical research community. 

The Team

The Zhang Lab has a creative team with multi-dimensional expertise in mathematics, biology, and physics

Research Summary

By investigating genomic variations in pediatric cancer—both somatic acquired alterations and germline predisposition variants, we aim to understand their role in cancer initiation and progression. We develop innovative software tools and collaborate with other investigators to discover novel targets including those for immunotherapy. Our group is also an instrumental contributor to the St. Jude Cloud initiative – a platform for sharing pediatric cancer data with the global research community.

Current areas of research include 1) discovery of non-coding driver variants in pediatric cancer by integrating epigenetics and 3D genome architecture.; 2) discovery of novel CAR-T targets; 3) therapy-related clonal hematopoiesis in pediatric cancer survivors; 4) optimization of computational methods to advance clinical genomics assays. 

Selected Publications

Download Software Tools

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Join us

We are always looking for highly self-motivated scientists/engineers with passion and talent to join us! People with experimental background are also encouraged to apply.

Current open positions

Contact us

We’d love to hear from you. If you have any questions or inquiries please get in touch with us.

Jinghui Zhang, PhD
Member, St. Jude Faculty
St. Jude Endowed Chair in Bioinformatics

Department of Computational Biology
MS 1135, Room IA-6038
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN, 38105-3678

262 Danny Thomas Place
Memphis, TN, 38105-3678 USA