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St. Jude Children's Research Hospital Home
St. Jude Family of Websites
Explore our cutting edge research, world-class patient care, career opportunities and more.
St. Jude Children's Research Hospital Home
Gene expression networks provide the underlying template for nervous system development. These fine-tuned, evolutionarily conserved networks have remarkable cell-type and developmental stage-specificity. For the first time, investigators in our department have the tools to blueprint gene expression networks on a genome-wide scale with single cell resolution.
Powered by such technological advancement, we seek to answer the following questions in our work to better understand the template for nervous system development.
Together, experimentalists work with data scientists to provide unprecedented new insights into genome function and structure to serve our mission.
Deciphering the pathogenesis and therapeutic vulnerabilities of pediatric high-grade glioma
Investigating the deregulation of developmental pathways in pediatric solid tumors
Interrogating the biology of pediatric brain tumors and developing preclinical models for therapeutic development
Leveraging multi-omic bulk and single-cell approaches to decipher molecular landscapes and developmental origins of medulloblastoma
Searching for insights into normal and diseased stem cell behaviors
Leveraging multi-omics approaches to understand genetic risk and developmental origins driving disease pathogenesis.
Understanding the link between cell polarity signaling and neuronal differentiation during cerebellar development