The Division of Molecular Oncology is a laboratory-based research group within the Department of Oncology. Our scientists lead dynamic, high impact research labs that are highly interactive with numerous collaborations among other St. Jude laboratories and shared resources.
Basic science investigations focus on the molecular and genetic determinants of pediatric cancers and the mechanisms that drive cancer development. Current areas of interest include investigations of oncogenes and tumor suppressor genes in tumor development, such as the SWI/SNF family of chromatin remodeling proteins, origins and pathology of pediatric solid tumors and leukemias, and the role of RNA splicing factor mutations in myeloid malignancies and bone marrow failure syndromes. By identifying the mechanisms underlying these diseases, Division laboratories have been able to translate novel targeted therapies to the clinic.
Exploring how the trajectory of developing cells get hijacked in the process of cellular transformation in pediatric cancer.
Exploring the function of the SWI/SNF (BAF) complex: chromatin, epigenetics and cancer.
Investigating the genetic mechanisms of myelodysplastic syndromes and developing targeted therapies with fewer side effects.
Targeting epigenomics and transcriptional regulation in pediatric solid tumors .
How components of the microenvironment, particularly blood platelets, immune cells, and the extracellular matrix, contribute to cancer metastasis.
Studying novel genomic targets in osteosarcoma.
Division of Molecular Oncology
MS 354, Room D5048
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Phone: (901) 595-0248
Fax: (901) 595-0817
Preferred contact method: email