Molecular Oncology

Divisional focus

The Division of Molecular Oncology is a laboratory-based research group within the Department of Oncology. Our scientists lead dynamic, high impact research labs that are highly interactive with numerous collaborations among other St. Jude laboratories and shared resources.

Basic science investigations focus on the molecular and genetic determinants of pediatric cancers and the mechanisms that drive cancer development. Current areas of interest include investigations of oncogenes and tumor suppressor genes in tumor development, such as the SWI/SNF family of chromatin remodeling proteins, origins and pathology of pediatric solid tumors and leukemias, and the role of RNA splicing factor mutations in myeloid malignancies and bone marrow failure syndromes. By identifying the mechanisms underlying these diseases, Division laboratories have been able to translate novel targeted therapies to the clinic.

Selected oncology publications

The St. Jude Children's Research Hospital After Completion of Therapy Clinic

Hudson. J Cancer Surviv, 2024

PAX3-FOXO1 dictates myogenic reprogramming and rhabdomyosarcoma identity in endothelial progenitors

Searcy et al. Nat Commun, 2023

A CRISPR-drug perturbational map for identifying new compounds to combine with commonly used chemotherapeutics

Lee et al, Geeleher. Nature Communications, 2023

Director

Mark Hatley, MD, PhD

Mark E. Hatley, MD, PhD
Associate Member
Director, Division of Molecular Oncology

Faculty Bio

Hatley Lab

Research and Treatment Team

Charles W. M. Roberts, MD, PhD

Charles W. M. Roberts, MD, PhD
Member, St. Jude Faculty
Director of the Comprehensive Cancer Center
Executive Vice President

Faculty Bio

Roberts Lab