Divisional focus

The Division of Molecular Oncology is a laboratory-based research group within the Department of Oncology. Our scientists lead dynamic, high impact research labs that are highly interactive with numerous collaborations among other St. Jude laboratories and shared resources.

Basic science investigations focus on the molecular and genetic determinants of pediatric cancers and the mechanisms that drive cancer development. Current areas of interest include investigations of oncogenes and tumor suppressor genes in tumor development, such as the SWI/SNF family of chromatin remodeling proteins, origins and pathology of pediatric solid tumors and leukemias, and the role of RNA splicing factor mutations in myeloid malignancies and bone marrow failure syndromes. By identifying the mechanisms underlying these diseases, Division laboratories have been able to translate novel targeted therapies to the clinic.


Research Programs

  • Mark Hatley, MD, PhD

    Associate Member, St. Jude Faculty
    Director, Division of Molecular Oncology
    Department of Oncology
    Comprehensive Cancer Center

    Research focus:
    Exploring how the trajectory of developing cells get hijacked in the process of cellular transformation in pediatric cancer

    Visit the Hatley Lab

  • Charles W. M. Roberts, MD, PhD

    Member, St. Jude Faculty
    Executive Vice President
    Director, Comprehensive Cancer Center
    Department of Oncology

    Research focus:
    Exploring the function of the SWI/SNF (BAF) complex: chromatin, epigenetics and cancer.

    Visit the Roberts Lab

  • Esther A. Obeng, MD, PhD

    Assistant Member, St. Jude Faculty
    Department of Oncology
    Comprehensive Cancer Center

    Research focus:
    Investigating the genetic mechanisms of myelodysplastic syndromes and developing targeted therapies with fewer side effects.

    Visit the Obeng Lab

  • Adam D. Durbin, MD, PhD

    Assistant Member, St. Jude Faculty
    Department of Oncology
    Comprehensive Cancer Center

    Research focus:
    Targeting epigenomics and transcriptional regulation in pediatric solid tumors 

    Visit the Durbin Lab


Contact us

Division of Molecular Oncology
MS 354, Room D5048
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678

Email: mark.hatley@stjude.org
Phone: (901) 595-0248
Fax: (901) 595-0817

Preferred contact method: email

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