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Explore our cutting edge research, world-class patient care, career opportunities and more.
St. Jude Children's Research Hospital Home
- Fundraising
Divisional focus
The Division of Molecular Oncology is a laboratory-based research group within the Department of Oncology. Our scientists lead dynamic, high impact research labs that are highly interactive with numerous collaborations among other St. Jude laboratories and shared resources.
Basic science investigations focus on the molecular and genetic determinants of pediatric cancers and the mechanisms that drive cancer development. Current areas of interest include investigations of oncogenes and tumor suppressor genes in tumor development, such as the SWI/SNF family of chromatin remodeling proteins, origins and pathology of pediatric solid tumors and leukemias, and the role of RNA splicing factor mutations in myeloid malignancies and bone marrow failure syndromes. By identifying the mechanisms underlying these diseases, Division laboratories have been able to translate novel targeted therapies to the clinic.
Selected oncology publications
Molecular Oncology Leadership
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Mark E. Hatley, MD, PhD
Associate Member, St. Jude Faculty
Director, Division of Molecular Oncology
Mark E. Hatley, MD, PhD
Associate Member, St. Jude Faculty
Director, Division of Molecular Oncology
Affiliations
Research Interests
- Cellular and molecular origins of embryonal rhabdomyosarcoma
- MicroRNAs in pediatric sarcomas
- Mouse models of pediatric sarcomas
- Development of novel therapies for pediatric sarcomas
Contact Information
Mark E. Hatley, MD, PhD
Molecular Oncology
MS 354, Room D5048F
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Molecular Oncology Faculty
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Adam D. Durbin, MD, PhD
Assistant Member, St. Jude Faculty
Adam D. Durbin, MD, PhD
Assistant Member, St. Jude Faculty
Research Interests
- Epigenetic and transcriptional regulation of high-risk pediatric cancers, including neuroblastoma and rhabdomyosarcoma
- Chemical biology and functional genomic perturbation of cancer systems biology
- Drug discovery for pediatric high-risk tumors
- Pathogenesis and modeling of rare tumors
Contact Information
Adam D. Durbin, MD, PhD
Molecular Oncology
MS 353, Room D5062F
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Lillian Macrae Guenther, MD
Assistant Member, St. Jude Faculty
Lillian Macrae Guenther, MD
Assistant Member, St. Jude Faculty
Affiliations
Research Interests
- Biologic investigation of novel dependency genes in pediatric osteosarcoma
- DNA damage repair mechanisms in pediatric osteosarcoma
- Development of novel therapeutic strategies for pediatric bone sarcomas
- Applications of genomic and chemical screening to identify targeted combinations in pediatric bone sarcomas
Contact Information
Lillian Macrae Guenther, MD
Molecular Oncology
MS 353, Room D5062D
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Alejandro Gutierrez, MD
Member, St. Jude Faculty
Alejandro Gutierrez, MD
Member, St. Jude Faculty
Affiliations
Research Interests
- Deciphering the molecular basis for oncogenic transformation and therapy resistance
Contact Information
Alejandro Gutierrez, MD
Oncology
MS 354
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Myriam Labelle, PhD
Associate Member, St. Jude Faculty
Myriam Labelle, PhD
Associate Member, St. Jude Faculty
Affiliations
Research Interests
- Role of the microenvironment during cancer metastasis
- Influence of platelets on tumor cell behavior
- Platelet-derived factors and signals involved in cancer progression and metastasis
Contact Information
Myriam Labelle, PhD
Molecular Oncology
MS 354, Room D5024G
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Min Ni, PhD
Assistant Member, St. Jude Faculty
Affiliations
Research Interests
- Genetic and metabolic control of development
- Pediatric cancer metabolism
- Metabolomics in systems biology
Contact Information
Min Ni, PhD
Molecular Oncology
MS 354, Room D5048E
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Esther A. Obeng, MD, PhD
Assistant Member, St. Jude Faculty
Esther A. Obeng, MD, PhD
Assistant Member, St. Jude Faculty
Affiliations
Research Interests
- Functional genomics
- Splicing factor mutations in Myelodysplastic Syndromes (MDS)
- Clonal hematopoiesis
- Epigenetic regulator mutations in MDS
- Identification of targeted therapies for bone marrow failure syndromes
Contact Information
Esther A. Obeng, MD, PhD
Molecular Oncology Division
MS 354, Room D5048C
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Charles W. M. Roberts, MD, PhD
Member, St. Jude Faculty
Executive Vice President
Director, Comprehensive Cancer Center
Lillian R. Cannon Comprehensive Cancer Center Director Endowed Chair
Charles W. M. Roberts, MD, PhD
Member, St. Jude Faculty
Executive Vice President
Director, Comprehensive Cancer Center
Lillian R. Cannon Comprehensive Cancer Center Director Endowed Chair
Affiliations
Research Interests
- Understanding the roles of SWI/SNF complex mutations and dysfunctional chromatin remodeling in cancer
- Improving the outcome of children with pediatric cancer
Contact Information
Charles W. M. Roberts, MD, PhD
Comprehensive Cancer Center
MS 281, Room C7045M
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Staff
Marie Josee Busse
Sr Administrative Specialist
marie.busse@stjude.org
Makayla Brown
Sr Administrative Specialist
makayla.brown@stjude.org
Stacy Throm, PhD
Director, Research Operations
stacy.throm@stjude.org
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Division of Molecular Oncology
MS 354, Room D5048
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: mark.hatley@stjude.org
Phone: (901) 595-0248
Fax: (901) 595-0817
Preferred contact method: email