St. Jude Family of Websites
Explore our cutting edge research, world-class patient care, career opportunities and more.
St. Jude Children's Research Hospital Home
- Fundraising
St. Jude Family of Websites
Explore our cutting edge research, world-class patient care, career opportunities and more.
St. Jude Children's Research Hospital Home
- Fundraising
The Division of Pharmaceutical Sciences operates with a mission to improve efficacy and reduce toxicity of drug therapy. Fundamental science has always been represented in our research portfolio, with faculty exploring mechanisms of drug transport, drug metabolism, and the genetic basis for interindividual differences in response to drug therapy. We continue to build on our groundbreaking efforts in pharmacogenomics and lead the world in discovery and clinical application. Our faculty are dissecting coding and non-coding regions of the genome to drive improvements in drug therapy, developing more accurate models of pediatric cancers for preclinical evaluation, and elucidating the basis of resistance to anticancer and anti-infective agents. The Division integrates expertise in pharmacokinetics, pharmacodynamics, and pharmacogenomics with state-of-the-art technologies to establish new knowledge and improve patient care.
Pharmaceutical Sciences Faculty
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Samuel W. Brady, PhD
Assistant Member, St. Jude Faculty
Samuel W. Brady, PhD
Assistant Member, St. Jude Faculty
Affiliations
Research Interests
- Integrating cancer genomics and pharmacology to discover new treatments for pediatric cancer
- Using cancer mutational signatures to develop novel treatment and prevention strategies
- Identifying therapeutic vulnerabilities linked to driver rearrangements and other mutations in cancer
- Translating genomic findings from patients into experimental approaches to improve cancer therapies
Contact Information
Samuel W. Brady, PhD
Pharmacy & Pharmaceutical Sciences
MS 313, Room I5308
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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William E. Evans, PharmD
Emeritus, St. Jude Faculty
Affiliations
Research Interests
- Investigating genomic determinants of toxicity and efficacy of anticancer agents, focusing on childhood acute lymphoblastic leukemia (ALL)
- Using genome-wide approaches, including gene expression profiling, single nucleotide polymorphism analyses, and whole exome/genome sequencing, to study drug resistance and pharmacologic targets
- Collaborating globally to optimize treatment strategies for ALL by translating genomic findings into diagnostics and therapies
- Continuing analysis of past data to improve the safety and effectiveness of cancer treatments for children
Contact Information
William E. Evans, PharmD
Pharmacy and Pharmaceutical Sciences
MS 313, Room I5108
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Markos Leggas, PhD
Member, St. Jude Faculty
Director, Center for Translational Pharmacology
Markos Leggas, PhD
Member, St. Jude Faculty
Director, Center for Translational Pharmacology
Affiliations
Research Interests
- Pharmacometabolomic methods to improve therapeutic outcomes and minimize toxicity in the context of pediatric clinical trials
- Pharmacometric and systems pharmacology approaches to enable drug development and guide therapy
- Development of transcription factor pharmacologic inhibitors
- Biomarkers and treatment of neonatal opioid withdrawal syndrome
Contact Information
Markos Leggas, PhD
Pharmacy and Pharmaceutical Sciences
MS 313, Room I5104
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 381053678
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Peijun Ma, PhD
Assistant Member, St. Jude Faculty
Affiliations
Research Interests
- Identifying genetic markers for the development of effective therapies to treat bacterial infections associated with antibiotic resistance and persistence
- Drug-induced bacterial heterogeneity
- Characterization of the microbiome in the context of antibiotic resistance and persistence
- Development of sequencing technology to study bacterial heterogeneity at the single-cell level and genome-wide scales
Contact Information
Peijun Ma, PhD
Pharmacy and Pharmaceutical Sciences
MS 313, Room I5106B
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Mary V. Relling, PharmD
Emeritus, St. Jude Faculty
Research Interests
- Clinical implementation of pharmacogenomic testing
- Host- and treatment-related risk factors affecting antileukemic therapy
- Improving the drug therapy of childhood leukemia
Contact Information
Mary V. Relling, PharmD
Pharmacy and Pharmaceutical Sciences
MS 313, Room I5112
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
- Clinical implementation of pharmacogenomic testing
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P. David Rogers, PharmD, PhD, FCCP
Member, St. Jude Faculty
Chair, Department of Pharmacy and Pharmaceutical Sciences
St. Jude Endowed Chair in Pharmaceutical Sciences
P. David Rogers, PharmD, PhD, FCCP
Member, St. Jude Faculty
Chair, Department of Pharmacy and Pharmaceutical Sciences
St. Jude Endowed Chair in Pharmaceutical Sciences
Affiliations
Research Interests
- Improvement of antifungal pharmacotherapy
- Understanding the molecular and genetic basis of antifungal drug resistance
Contact Information
P. David Rogers, PharmD, PhD, FCCP
Pharmacy and Pharmaceutical Sciences
MS 313, Room I5112
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Jeffrey M. Rybak, PharmD, PhD
Assistant Member, St. Jude Faculty
Jeffrey M. Rybak, PharmD, PhD
Assistant Member, St. Jude Faculty
Affiliations
Research Interests
- Improvement in the treatment strategies for pediatric patients with invasive fungal infections
- Genetic and molecular determinants of antifungal treatment failures
- Discovery of therapeutic strategies to overcome difficult-to-treat fungal pathogens
- Creation of novel genetic and molecular tools to advance the study of pathogenic fungi
Contact Information
Jeffrey M. Rybak, PharmD, PhD
Pharmacy and Pharmaceutical Sciences
MS 313, Room I5304
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Daniel Savic, PhD
Associate Member, St. Jude Faculty
Daniel Savic, PhD
Associate Member, St. Jude Faculty
Affiliations
Research Interests
- Investigating gene regulatory activity and networks in acute lymphoblastic leukemia (ALL)
- Linking gene regulatory responses to chemotherapy resistance
- Evaluating the influence of noncoding genetic variants on ALL treatment
Contact Information
Daniel Savic, PhD
Pharmacy and Pharmaceutical Sciences
MS 313, Room I5104
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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John D. Schuetz, PhD
Member, St. Jude Faculty
Affiliations
Research Interests
- Role of ABC transporters in response to chemotherapy
- Biological function of ABC transporters
- Regulation of ABC transporters
- Metabolism in physiology and pathophysiology
Contact Information
John D. Schuetz, PhD
Pharmacy and Pharmaceutical Sciences
MS 313, Room I5301
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Clinton F. Stewart, PharmD
Emeritus, St. Jude Faculty
Affiliations
Research Interests
- CNS and tumor penetration of novel agents used to treat pediatric CNS tumors in relevant mouse models
- Pharmacokinetic and pharmacodynamic modeling and simulation to derive safe and effective anti-cancer drug regimens for infants and young children with brain tumors
- Novel methods to optimize drug exposure in children with cancer (e.g., pharmacokinetically guided dosing)
- Improving Drug Therapy for Children with Brain Tumors
Contact Information
Clinton F. Stewart, PharmD
Pharmacy and Pharmaceutical Sciences
MS 313, Room I5309
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Jun J. Yang, PhD
Member, St. Jude Faculty
Division Director, Pharmacy Sciences
Vice-Chair, Department of Pharmacy and Pharmaceutical Sciences
Endowed Chair in Pharmacogenomics
Jun J. Yang, PhD
Member, St. Jude Faculty
Division Director, Pharmacy Sciences
Vice-Chair, Department of Pharmacy and Pharmaceutical Sciences
Endowed Chair in Pharmacogenomics
Affiliations
Research Interests
- Understanding the genetic basis of inter-patient variability in anticancer drug response
- Pharmacogenomics of anti-leukemia drug toxicities
- Genomics of anti-leukemia drug sensitivity and resistance (especially molecularly targeted therapeutics)
Contact Information
Jun J. Yang, PhD
Pharmacy and Pharmaceutical Sciences
MS 313, Room I5104
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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