Finding new cures for children with cancer and life-threatening diseases is central to the St. Jude mission. Working closely together, our scientists and clinicians translate laboratory breakthroughs into novel treatment options for patients at St. Jude—and around the world.
Small molecule discovery
From high-throughput screening to tailored molecular design, our investigators pursue the full spectrum of approaches to identify small molecules with excellent therapeutic potential. On-campus resources include:
A unique small molecule library with more than 800,000 carefully curated, purified compounds. The library is one of the largest at any academic institution and continues to expand. To date, St. Jude chemists have synthesized more than 50,000 of these compounds.
One of the world's best “repurposing” collections of FDA-approved drugs. This collection includes the active ingredients from most approved drugs and many developmental therapeutics. These drugs are available to rapidly explore for new uses in treating childhood diseases.
A high-throughput compound screening facility focused solely on generating new treatments for children. The robots—each named by a St. Jude patient—can screen 50,000 compounds for bioactivity per day.
An extraordinary culture of collaboration. The St. Jude campus and culture have been deliberately designed to spark connections between clinicians and scientists to give drug discovery projects the greatest chance of real-world success.