Research

Learn about published research as well as leading-edge basic and translational research initiatives from St. Jude laboratories.

Secrets of aggressive, deadly cancers revealed in African yeast

Janet Partridge, PhD

Learn how a deadly pediatric cancer mutates a protein to cause a series of cellular malfunctions.

Experimental cancer drug shows early promise against flu

Paul Thomas, PhD

The flu hijacks upper lung cells and turns them into flu factories. Read how an experimental cancer drug targets the flu’s fuel and shuts the factory down.

Inheriting cancer: Leading the conversation about increased genetic risk

Kim E. Nichols, MD

Read how experts came together to create surveillance recommendations for children and young adults with hereditary conditions that predispose them to cancer.

Childhood Solid Tumor Network shares samples, promotes cures

Michael Dyer, PhD

The CSTN provides the world’s largest collection of pediatric cancerous tumors for research into novel treatments. Find out more about available resources.

New CAR T-Cell therapy for pediatric ALL approved, more to come

Stephen Gottschalk, MD

The FDA has approved Kymriah, the first CAR T-cell therapy for acute lymphoblastic leukemia. Find out how St. Jude is planning to use this novel treatment.

Cell necroptosis: Can ESCRT-III proteins protect cells from the kill switch?

Douglas R. Green, PhD

Find out how a newly discovered protein can give your body’s doomed cells a second chance at life.

Cracking the epigenetic code of retinoblastoma

Michael Dyer, PhD

St. Jude scientists, in work published in the journal Neuron, used powerful analytical tools to map what is known as the “epigenetics” of the retina.

Discovering new molecular switches to control autoinflammatory disease

Thirumala-Devi Kanneganti, PhD

Is Ptpn6, a controlling gene, linked with the master immune switch IL-1 alpha? Can this link be mapped to help pinpoint immune system response? Find out more.

Rigor, reproducibility and resources take center stage

Clay Christian, PhD

NIH seminar elucidates new guidelines for grant-funded research as well as allocation of monies to more labs.

Childhood cancer survivorship gains offers GWAS opportunities for researchers

Greg Armstrong, MD, MSCE

Find out how to access GWAS data from the Childhood Cancer Survivor Study, to help answer how genetics.