Research

Learn about published research as well as leading-edge basic and translational research initiatives from St. Jude laboratories.

Lisa Jacola
Lisa Jacola

Pain may be a risk factor for learning problems in childhood cancer survivors

Mary Powers

Researchers are focusing on treatment-related pain as another way to reduce the risk of learning and memory problems in survivors of childhood leukemia.

CoNGA
CoNGA

CoNGA: Deciphering the dance of T-cell differentiation

Stefan Schattgen, PhD

St. Jude scientists have created an algorithm to help group T-cells by their function by evaluating two different types of data, T-cell receptor sequences and gene expression.

Haitao Pan, PhD
Haitao Pan, PhD

St. Jude biostatisticians create a novel clinical trial design software

St. Jude Progress

Description: St. Jude biostatisticians have developed a new method for designing phase 2 clinical trials with a small sample size. The approach uses a mathematical model called Bayesian probability . The researchers created free software to implement the process.

Meeting graphic
Meeting graphic

Bringing Chemistry to Medicine: Transcription therapy symposium is set for July 22 and 23

Mike O’Kelly

St. Jude will host the virtual Bringing Chemistry to Medicine Symposium July 22–23. The inaugural event in 2020 prompted a researcher in India to become a visiting scientist at St. Jude. Register for the event.

Illustration depicting all the different things that occur during rehabilitation through an arch with symbols representing different rehabilitation ideas. A path goes between many things going on, such as jumping rope, reading and children playing.
Illustration depicting all the different things that occur during rehabilitation through an arch with symbols representing different rehabilitation ideas. A path goes between many things going on, such as jumping rope, reading and children playing.

Identifying risks and restrictions: Rehabilitation and cancer survivorship

St. Jude Communications Department

Kristin Lyons, director of Rehabilitation Services, and Jessica Sparrow, Lead Occupational Therapist, worked as part of a team of oncology rehabilitation providers from pediatric institutions across the country to co-author a recent Seminars in Oncology Nursing article, which provides a comprehensive overview of rehabilitation screening, assessment, and intervention for children with cancer.

posterior fossa
posterior fossa

Getting to the bottom of a medulloblastoma mystery

Erin Podolak, MA

Posterior fossa syndrome develops in some children following surgery for the brain tumor medulloblastoma. St. Jude research offers fresh insight into the mysterious syndrome and advice on how to avoid it.

Leaf with water droplets
Leaf with water droplets

For the growing number of childhood cancer survivors, five-year survival is just the beginning

AnnaLynn Williams, PhD

As cancer survivorship changes, new benchmarks must be set to redefine survivorship research and treatment success.

EKG screen
EKG screen

The heart of the matter – cancer survivors and heart disease

Matthew J. Ehrhardt, MD

Cancer treatments can result in damage to the heart both during treatment and years following completion of therapy. As many cancer survivors are now living longer into adulthood, we’re gaining a better understanding of some of the late effects of cancer treatments that we weren’t able to observe before.

A 3D print of influenza virus shows the yellow surface covered with proteins called hemagglutinin (colored blue) and neuraminidase (colored red) that enable the virus to enter and infect human cells. Image provided by the National Institutes of Health.
A 3D print of influenza virus shows the yellow surface covered with proteins called hemagglutinin (colored blue) and neuraminidase (colored red) that enable the virus to enter and infect human cells. Image provided by the National Institutes of Health.

Immune markers offer clues to antibody production in response to flu

Mary Powers

Scientists are learning more about antibody production in response to flu, including how they develop from helper T cells and monocytes.

Blocking the progression of pre-leukemic disorders
Blocking the progression of pre-leukemic disorders

Blocking the progression of pre-leukemic disorders

Erin Podolak, MA

Genetic changes in the biology of blood cells can lead them down a path to cancer. This researcher is figuring out how that happens.