Research

Learn about published research as well as leading-edge basic and translational research initiatives from St. Jude laboratories.

Melissa Hudson video screenshot
Melissa Hudson video screenshot

It’s in the genes: research reveals obstacles on the road to health for cancer survivors

Alex Generous, PhD

St. Jude scientists are leading research into the genetics of childhood cancer survivorship to understand and prevent the risk of chronic disease in survivors.

Peter McKinnon, Kathryn Stephenson, Richard Finkel
Peter McKinnon, Kathryn Stephenson, Richard Finkel

Two Years of the Pediatric Translational Neuroscience Initiative

Alex Generous, PhD

St. Jude initiative aims to change the outlook for children with catastrophic neurological diseases.

Xu Yang and Yizhen Li in a laboratory
Xu Yang and Yizhen Li in a laboratory

T cells are key to maintaining cancer remissions from chemotherapy

Erin Podolak, MA

Stimulating the adaptive immune response can improve outcomes for ALL treated with chemotherapy.

Paul Thomas and Joshua Wolf
Paul Thomas and Joshua Wolf

St. Jude researchers answer COVID questions

Erin Podolak, MA

St. Jude research has advanced understanding of the immune response to SARS-CoV-2 infection and vaccination. Here is what the findings mean for you.

Fabio Demontis
Fabio Demontis

Research points to a way to reduce cachexia, a cancer-induced muscle wasting disorder

Erin Podolak, MA

Muscle signaling provide clues for treatment of the muscle-wasting disorder cachexia, which affects cancer patients.

Stephen Mack, MD, PhD
Stephen Mack, MD, PhD

Metabolic processes may yield a new therapeutic window for hard-to-treat brain tumors

Erin Podolak, MA

In his laboratory at St. Jude, Stephen Mack, PhD, is researching how metabolic and epigenetic pathways might be perturbed to help treat DIPG, a lethal childhood brain tumor.

Hippocampus illustration
Hippocampus illustration

St. Jude symposium to focus on hippocampus imaging in childhood cancer patients and survivors

Alex Generous, PhD

St. Jude Children’s Research Hospital’s Department of Diagnostic Imaging is hosting their 3rd Annual Scientific Symposium, “Imaging Structure and Functions of the Hippocampus” on February 25.

Lisa Jacola
Lisa Jacola

Pain may be a risk factor for learning problems in childhood cancer survivors

Mary Powers

Researchers are focusing on treatment-related pain as another way to reduce the risk of learning and memory problems in survivors of childhood leukemia.

CoNGA
CoNGA

CoNGA: Deciphering the dance of T-cell differentiation

Stefan Schattgen, PhD

St. Jude scientists have created an algorithm to help group T-cells by their function by evaluating two different types of data, T-cell receptor sequences and gene expression.

Haitao Pan, PhD
Haitao Pan, PhD

St. Jude biostatisticians create a novel clinical trial design software

St. Jude Progress

Description: St. Jude biostatisticians have developed a new method for designing phase 2 clinical trials with a small sample size. The approach uses a mathematical model called Bayesian probability . The researchers created free software to implement the process.