The receptor for the IL-35 cytokine closely associated with Tregs can be used to develop methods to block or augment IL35R signaling to block or boost, respectively, IL-35 activity. This could be used to treat autoimmune and inflammatory diseases. Methods that block/inhibit IL35R signaling could be used to treat any condition in which the IL-35-mediated activity of Tregs is shown to blocking/limiting disease resolution such as cancer and chronic inflammatory disease.
Receptor,IL-35 cytokine ,Tregs, autoimmune and inflammatory disease, cancer
Granted Patents or Published Applications
US patent 10,392,431
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