A research team here at St. Jude, led by Howard Hughes Medical Investigator Brenda Schulman, PhD, have discovered a peptide that inhibits cullin neddylation, a process required for proper cell proliferation. It could be useful for drug screening and peptide screening applications; which could have therapeutic potential for treating cancer, inflammatory disorders and/or or pathogenic infections.
Peptide inhibitor, screening method, drug discovery, enzyme, cancer, pathogen, inflammation
Granted Patents or Published Applications
A patent application covering this peptide, its pharmaceutical use and screening methods for identifying additional inhibitors is currently pending.
Related Scientific References
The research underlying this discovery was reported last fall as Scott, D.C. et al., Science 334: 674-678 (Nov. 4, 2011).
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