Cancer Predisposition Family Conference on DICER1

Thursday & Friday, November 5 & 6, 2020

 

Overview

On behalf of the Cancer Predisposition Program at St. Jude Children’s Research Hospital, we invite you to our second Cancer Predisposition Conference November 5-6, 2020.

This year’s event will focus on DICER1. This conference will allow families living with DICER1 and medical professionals to learn about the latest scientific advances as well as other important issues such as cancer screening, coping, communication and for the young adults — learning how to navigate the medical system and take responsibility for your health care as you march out on your own.

CME Credit

St. Jude Children's Research Hospital is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

St. Jude Children’s Research Hospital designates this live activity for a maximum of 7.5 AMA PRA Category 1 CreditsTM. Physicians should only claim the credit commensurate with the extent of their participation in the activity.

Speakers

Kim E. Nichols, MD

Kim E. Nichols, MD
Director, Cancer Predisposition Division
St. Jude Children's Research Hospital

 

Kim E. Nichols, MD
Conference Chair

Dr. Nichols is the Director of the Cancer Predisposition Division at St. Jude Children's Research Hospital. As a pediatric oncologist, her research interests are in the molecular mechanisms that provide protection against viral infections and cancer. Her overarching goals are to understand how defects in these mechanisms contribute to disease and use this information to develop more effective treatments for children with increased genetic risk for infection and/or malignancy.

Towards this end, Dr. Nichols' research focuses on identifying novel genetic causes of childhood cancer, optimizing methods of tumor surveillance for children with increased cancer risk, evaluating the factors that influence parent and adolescent decision making and communication around genetic testing for heritable cancer risk, understanding the behavioral and psychological impacts of cancer genetic testing on children and their families, and increasing understanding and developing new therapies for malignant and non-malignant hematologic disorders, including B-cell leukemias and lymphomas, hemophagocytic lymphohistiocytosis and Epstein-Barr virus-associated lymphoproliferations.

Andrew Bauer, MD

Andrew J. Bauer, MD
Associate Professor of Pediatrics
Perelman School of Medicine, University of Pennsylvania

Andrew J. Bauer, MD

Andrew J. Bauer, MD, is an associate professor of Pediatrics at the Perelman School of Medicine, University of Pennsylvania and serves as the director of Children's Hospital of Philadelphia's Thyroid Center. A native of Buffalo, NY, Dr. Bauer completed his undergraduate at Canisius College and his medical degree at the State University of New York at Buffalo School of Medicine, his pediatric training at Madigan Army Medical Center, Fort Lewis, Tacoma, WA, and his pediatric endocrine training at the National Capital Consortium, Uniformed Services University, Bethesda, MD. In 2013, Dr. Bauer retired from the United States Army after 29 years of service, to include two combat tours in Iraq.

Dr. Bauer’s clinical and research interests are focused on the study of pediatric thyroid disorders, including hyperthyroidism, hypothyroidism, thyroid nodular disease, thyroid cancer, and familial thyroid tumor syndromes. Within this field, he has published more than 110 manuscripts, chapters and reviews and is a regularly invited lecturer and visiting professor at international meetings and academic institutes. Dr. Bauer serves as a medical consultant for the Thyroid Cancer Survivors Association and as the thyroid consultant for the International Pleuropulmonary blastoma/DICER1 registry.

Tiffany Blair, MSSW, LMSW

Tiffany Blair, MSSW, LMSW
Pediatric Oncology Social Worker
St. Jude Children's Research Hospital

Tiffany Blair, MSSW, LMSW

Tiffany Blair, MSSW, LMSW earned her Master of Social Work degree from Union University School of Social Work and has worked in various direct patient care settings for the past 13 years, including Shelby County Health Department, Memphis Veteran Affairs Medical Center and Camelot Care Center. She currently works as a Pediatric Oncology Social Worker at St. Jude Children’s Research Hospital. Her role includes facilitating programs and services designed to support children, teens, young adults and parents impacted by cancer.

William D. Foulkes, M.B.BS, Ph.D., F.R.S.C.

William D. Foulkes, MBBS, PhD, FRSC 
James Gill Professor, Departments of Human Genetics and Oncology
McGill University

William D. Foulkes, MBBS, PhD, FRSC 

William D. Foulkes, MBBS, PhD, FRSC is a James McGill Professor in the Departments of Human Genetics and Oncology at McGill University. He is senior clinician-scientist who has worked in the area of inherited susceptibility to cancer for over 25 years. His research career centers on understanding inherited susceptibility to cancer. The direction of his program has been to move from cancer gene mutation discovery to clinical applications. This work is intimately associated with his clinical career: this process has enabled him to directly use patients as a source of discovery and to rapidly translate the results of our work for the benefit of patients and their families. Over the years, he has supervised many undergraduate and graduate students as well as research and medical fellows. To complement his own expertise, he has developed a broad collaborative network of clinical, pathology and basic research experts with relevant specialties that are systematically involved in all aspects of his research program.

Mark Hatley, MD, PhD

Mark Hatley, MD, PhD
Faculty Member, Department of Oncology, Division of Molecular Oncology
St. Jude Children's Research Hospital

Mark E. Hatley, MD, PhD

Dr. Hatley joined St. Jude in 2011 after completing his fellowship in Pediatric Hematology/Oncology from the University of Texas Southwestern Medical School at Dallas and Children’s Medical Center, Dallas. Dr. Hatley also earned his medical degree and his doctorate in Cellular Regulation in the lab of Nobel Laureate Alfred G Gilman from the same institution. Previously, he received his Bachelor of Science degree in Chemistry from the University of Central Oklahoma.

Dr. Hatley is now a faculty member in the department of Oncology. He works in the division of Molecular Oncology and is an attending oncologist in the Solid Tumor division, with his specialty being rhabdomyosarcoma.  Dr. Hatley’s lab has developed model systems to understand the underpinnings of rhabdomyosarcoma and are particularly interested in how normal child development provides a unique environment for cancer formation. 

A native of Edmond, Oklahoma, Dr. Hatley enjoys his free time with his wife and four children.

D. Ashley Hill, MD

D. Ashley Hill, MD
Chief, Department of Pathology

D. Ashley Hill, MD

Ashley Hill is a pediatric pathologist with clinical and research interests in pediatric solid tumors. She obtained a BS in Biomedical Engineering at Northwestern University and then completed her MD at Washington University in St. Louis. After a very long year of internal medicine internship, she trained in anatomic pathology and pediatric pathology with Pepper Dehner at Washington University. Her first job as a surgical pathologist at St. Jude Children’s Research Hospital where she ultimately spent three years. It was a wonderful experience working with the oncologists, radiologists, pathologists and tremendous support staff for those three years. She returned to Washington University to work with Pepper in pediatric pathology and in collaboration with the International Pleuropulmonary Blastoma/DICER1 Registry (IPPBR), performed a family study that linked pleuropulmonary blastoma (PPB) to germline DICER1 mutations. She moved to Washington DC in 2008 to became Chief of Anatomic Pathology at Children’s National Hospital, where she worked with another great team of oncologists, radiologists, pathologists and support staff. Her laboratory at Children’s continues to work with the IPPBR and is now focused on identifying safer and more effective therapies in patient-derived xenograft mouse models. In 2013, she started ResourcePath, a clinical laboratory company devoted to improving the care of children with cancer. ResourcePath’s first development is a test that detects PPB tumor DNA in the blood which we hope will help us determine if PPB tumor cells remain after surgery and if so, are they being eradicated by chemotherapy. Ashley wants to thank all the children and families that have participated in PPB and DICER1 research and inspire us every day to make a difference for children with cancer. 

Anthony Liu, MD

Anthony Liu, MD
Clinical Fellow, Department of Oncology
St. Jude Children's Research Hospital

Anthony Liu, MD

Anthony P.Y. Liu, MBBS, MS, received his medical degree with honors from the University of Hong Kong in 2009. He completed a residency in pediatrics and training in pediatric hematology/oncology at Queen Mary Hospital, Hong Kong, and obtained a Master's degree in genetic counseling. A keen clinician-scientist with interest in pediatric central nervous system tumors, Dr Liu joined St. Jude Children’s Research Hospital as a Pediatric Neuro-Oncology Fellow in 2017. His ongoing research is focused on clinical-molecular characterization of rare pediatric brain tumors, including pineoblastoma and other central nervous system embryonal tumors, as well as on the utility of liquid biopsy for children with brain tumors.

Kris Ann P. Schultz, MD

Kris Ann P. Schultz, MD
Pediatric Oncologist
Children's Minnesota

Kris Ann P. Schultz, MD

Kris Ann P. Schultz, MD, is a pediatric oncologist at Children's Minnesota. She graduated summa cum laude from Drake University (BA) and summa cum laude from Loyola University (MD). She completed her pediatric residency and pediatric hematology/oncology fellowship at the University of Minnesota and received a Master of Science degree in clinical research during the course of her fellowship. Dr. Schultz is the Principal Investigator for the International Pleuropulmonary Blastoma (PPB) and DICER1 Registry and the Principal Investigator and founder of the International Ovarian and Testicular Stromal Tumor Registry. Her current research focuses on development of novel treatments for DICER1-related tumors. She is also active in the development of guidelines and surveillance strategies for individuals with DICER1 variation. She is a member of the Alpha Omega Alpha Honor Medical Society and serves as Co-Director for Cancer and Blood Disorders Research at Children's Minnesota. Dr. Schultz joined the Hematology Oncology program at Children's of Minnesota in 2008 and has particular interest and expertise in the care of children with pleuropulmonary blastoma, ovarian tumors and other rare childhood cancers.

Katianne Sharp, PhD

Katianne Sharp, PhD
Instructor, Department of Psychology
St. Jude Children's Research Hospital

Katianne Sharp, PhD

Katianne Howard Sharp, PhD, is an Instructor in the Department of Psychology at St. Jude Children’s Research Hospital. She completed her doctorate in Clinical Psychology with a focus on children and families at The University of Memphis. She completed clinical internship at The University of Mississippi Medical Center Consortium and a research fellowship in pediatric psychology at Nationwide Children’s Hospital. Dr. Sharp joined the Department of Psychology at St. Jude in 2018 as a Clinician-Scientist, with research and clinical interests in cancer predisposition. Her research is focused on parent and child adjustment and communication in the context of cancer predisposition disclosed during childhood.

Preliminary Agenda

Thursday, November 5, 2020

Time
Event
9:00 am Welcome, Conference Information and Introductions – Dr. Kim Nichols
9:15 - 9:45 am Dr. Kris Ann Schultz – A Whirlwind Tour of PPB/DICER1: History and Clinical Aspects 
9:45 - 10:00 am Questions for Dr. Schultz
10:00 - 10:15 am Break
10:15 - 10:45 am Dr. Andrew Bauer – The Thyroid and DICER1
10:45 - 11:00 am  Questions for Dr. Bauer
11:00 am - 2:00 pm Lunch Break
2:00 - 2:15 pm Welcome Back!
2:15 - 2:45 pm Dr. Mark Hatley – DICER1 and RMS
2:45 - 3:00 pm Questions for Dr. Hatley
3:00 - 3:15 pm Break
3:15 - 3:45 pm Dr. Ashley Hill - Using Genetics to Reach for a Cure
3:45 - 4:00 pm Questions for Dr. Hill
4:00 - 4:15 pm Wrap up for the day

Friday, November 6, 2020

Time
Event
9:00 am Welcome to Day 2 – Dr. Kim Nichols
9:15 - 9:45 am Dr. Will Foulkes – DICER1 Biology 101
9:45 - 10:00 am Questions for Dr. Foulkes
10:00 - 10:15 am Break
10:15 - 10:45 am Dr. Anthony Liu – DICER1 and CNS Tumors
10:45 - 11:00 am Questions for Dr. Liu
11:00 am - 1:00 pm Lunch Break
1:00 - 1:15 pm Welcome Back!
1:15 - 1:45 pm Tiffany Blair, MSSW – Living with DICER1
1:45 - 2:00 pm Questions for Tiffany
2:00 - 2:15 pm Break
2:15 - 3:15 pm Dr. Katianne Sharp – Breaking the Ice – Talking about DICER1 with Your Children and Other Family Members
3:15 - 3:30 pm Questions for Dr. Sharp
3:30 - 4:00 pm Presentation from a Family Living with DICER1
4:00 - 4:30 pm Q&A Panel Session for Families with Genetic Counselors and Others
4:30 pm Conference Closing Remarks – Dr. Kim Nichols

Register for the Conference

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