Evaluating human movement and performance in children and adolescents during and after treatment for cancer or other catastrophic disease
The ability to dynamically move the body is a hallmark of an active, healthy life. Yet, for children with cancer, the presence of disease and exposure to treatment affect their abilities to move, play, participate in sports and sometimes even engage in everyday activities. My research team evaluates human movement and performance in children and adolescents during treatment for cancer or other catastrophic disease and in children, adolescents, and adults who have completed cancer therapy. Following patients from diagnosis throughout life, my research aims to better understand physical well-being and develop interventions to remediate or prevent the loss of physical function.
Evaluating movement and physical well-being in patients and survivors of childhood cancer is central to research in human performance. As part of the Department of Epidemiology and Cancer Control, my colleagues and I conduct a thorough evaluation of an individual’s function and movement in the Human Performance Lab. These evaluations range from small sensory-function measurements in a fingertip to comprehensive measurements of mobility, cardiopulmonary fitness, joint range-of-motion, muscle strength, vascular health, and peripheral nervous system integrity.
Our research within the Human Performance Lab involves children who currently receive treatment for leukemia and lymphoma, brain tumors, other solid tumors, sickle cell disease, and spinal muscular atrophy. We evaluate cancer survivors enrolled in the After Completion of Therapy Clinic (ACT) and St. Jude LIFE study. We are among the world leaders in cardiopulmonary fitness testing in both patients and survivors of pediatric cancer. We also have expertise in the assessment of cardiac autonomic and peripheral vascular dysfunction, isometric and isokinetic muscle strength and balance testing, peripheral nervous system assessment and measurement of normal movement development, and adaptive physical function. In collaboration with diagnostic imaging, we measure muscle and bone quality and quantity. Beyond fitness testing, we study the impact of physical activity, exercise, and diet on long term health in our patient populations.
Our translational approaches to improve physical and overall health in children and survivors include interventions that employ exercise, physical rehabilitation, dietary strategies, mechanical stimulation, telehealth, and interactive mobile technology to restore or prevent loss of cardiac, pulmonary, musculoskeletal, neurologic, and adaptive function. Interventions are individualized and incorporate families. We currently offer an exercise intervention for children receiving radiation therapy, and a telehealth-based cardiac rehabilitation program for cancer survivors who have low fitness. In another effort powered by virtual, remote-based approaches, we partner with the Children’s Oncology Group to promote physical activity in children after they receive cancer therapy.
Our commitment to improving the quality of life for patients and survivors of childhood cancer fuels all aspects of our research and interventional work.
Dr. Kirsten Ness is a physical therapist, clinical epidemiologist, and a Member in the Department of Epidemiology and Cancer Control at St. Jude. In her research work, she focuses on recognizing, describing, and remediating functional limitations in childhood cancer survivors. As Principal Investigator of the Human Performance Lab at St. Jude, Ness collaborates with other investigators to understand physiological impairments and problems with movement and physical function in patients and survivors of childhood cancer. Outside her research work, she is a member of the Childhood Cancer Survivor Study (CCSS). She also serves on several editorial boards and teaches the Introduction to Epidemiology course within the St. Jude Graduate School.
Kirsten K. Ness, PT, PhD, FAPTA
Department of Epidemiology and Cancer Control
St. Jude Children's Research Hospital