Overview

The Antibody Discovery Collaborative Center supports the development of human and murine monoclonal antibodies and other biologic modalities. Our goal is to promote basic and translational studies concentrated on the microbes responsible for catastrophic infectious diseases. The center operates an integrated platform for biologics discovery, expression, and characterization. To enable the generation of diverse lead sequences, we use both in vivo and in vitro methodologies to mine repertoires from animal immunization and synthetic antibody libraries. The center combines high-throughput screening and informatics to deliver diverse panels of binders against targets important for infectious disease research and beyond. 

Antibody Discovery Workflows. Image created with BioRender.


Impact

The rising threat of antimicrobial-resistant pathogens demands innovative, strategic and durable treatment options to combat infectious diseases. Antibody discovery provides the platform and necessary tools to develop such treatments. With experience in basic and translational research spanning infectious diseases, structural biology and cancer immunotherapy, the Antibody Discovery Collaborative Center jumpstarts therapeutic antibody discovery by providing customized antibody solutions.

Services

Planning

Project planning for antibody discovery and onboarding of discovery workflows

Design

Antigen design and modality-based discovery platform choice

Delivery

Immunization/display-based approaches for delivery of antibody sequences for downstream expression and characterization 

Assessment

Early-stage characterization including SPR and developability assessment

About the Director

Sunandan Banerjee

Dr. Sunandan Banerjee obtained his PhD from University of Vermont in protein design and trained at the University of Toronto in synthetic antibody technologies. He has worked in biotech and big pharma and has over 10 years of progressive experience in therapeutic antibody development in both academia and industry. His primary interests lie in developing antibody discovery workflows, repertoire analysis to drive synthetic antibody library development and utilizing in vivo and in vitro technologies to drive therapeutic monoclonal antibody (mAb) discovery.

The team

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    Azady Pirhanov, PhD

    Scientist

Contact us

Sunandan Banerjee, PhD 
Department of Host Microbe Interactions
MS 221, Room D2006A

St. Jude Children’s Research Hospital

262 Danny Thomas Place
Memphis, TN, 38105-3678 USA
sunandan.banerjee@stjude.org