A St. Jude study linked inherited mutations in the BRCA2 gene with a higher risk of non-Hodgkin lymphoma.
The work focused on childhood cancer survivors. The team looked at 1,380 survivors of pediatric lymphoma.
“BRCA genes have been linked to adult cancer for many years,” said Zhaoming Wang, PhD, of Epidemiology and Cancer Control and Computational Biology. “Our study shows a relationship between BRCA2 and non-Hodgkin lymphoma in childhood cancer survivors.”
Genetic counseling and BRCA2 testing could be useful for survivors of childhood non-Hodgkin lymphoma. Survivors with a family history of BRCA2-associated cancers may also be tested.
A report on this work was published in JAMA Oncology.