2021 Archive

Nickhill Bhakta and Nancy Bolous
Nickhill Bhakta and Nancy Bolous
Outreach

Bridging the pediatric cancer budgeting gap in national cancer control plans

Alex Generous, PhD

A new rapid budgeting tool increases the likelihood pediatric cancer will be included in national cancer control plans globally.

Investigator Insights

5 Questions for Laura Jolovic

Erin Podolak, MA and Laura Jolovic

Meet St. Jude radiation therapist Laura Jolovic and learn how she provides care for children with cancer as well as mentors students interested in a career in pediatric radiation oncology.

3 men in a lab
3 men in a lab
Research

CRISPR kickstarts combination drug discovery for neuroblastoma

Alex Generous, PhD

A CRISPR screen reveals a potential combination therapy for relapsed neuroblastoma.

Outreach

Building blocks: St. Jude Global guides reestablishment of health care capacity during crisis

Erin Podolak, MA

St. Jude Global helps provide a framework for rebuilding health care capacity after a crisis.

Research

Finding the big-TIME players holding back CAR T–cell therapy for high-grade gliomas

Alex Generous, PhD

Explore how tumor-associated macrophages shape CAR T-cell therapy efficacy in high-grade gliomas.

Alaa Refaat, PhD
Alaa Refaat, PhD
Investigator Insights

5 Questions for Alaa Refaat

Erin Podolak, MA and Alaa Refaat, PhD

Meet St. Jude senior scientist Alaa Refaat, PhD, and learn about his work to develop treatments for childhood brain tumors using chemical biology approaches.

(L to R) First author Prahalathan Pichavaram, PhD, corresponding author Andrew Murphy, MD, St. Jude Department of Surgery and co-author Carolyn Jablonowski, PhD.
(L to R) First author Prahalathan Pichavaram, PhD, corresponding author Andrew Murphy, MD, St. Jude Department of Surgery and co-author Carolyn Jablonowski, PhD.
Research

Ribosome production presents a new therapeutic opportunity against Wilms tumor

Alex Generous, PhD

Discover how disruption ribosomes creation provides promise for “undruggable” cancers.

People sitting around a table
People sitting around a table
Outreach

St. Jude Mentorship Roundtable

Alex Generous, PhD

Watch scientific mentors discuss the value of mentorship.

Ashraf Mohommed and Aseem Ansari
Ashraf Mohommed and Aseem Ansari
Research

Just like the real thing: Synthetic gene expression regulators demonstrate success

Brian O'Flynn, PhD

See how Aseem Ansari's SynGRs target BET proteins, offering potential for treating diseases like Friedreich’s ataxia and advancing BET domain understanding

STLS Retro illustration
STLS Retro illustration
Outreach

Echoes of Excellence: The speakers who shaped the Danny Thomas Lecture Series

Brian O'Flynn, PhD

Follow the path of illustrious speakers that have spoken at St. Jude’s keystone lecture series.

Lisa Jacola
Lisa Jacola
Research

Pain may be a risk factor for learning problems in childhood cancer survivors

Mary Powers

Researchers are focusing on treatment-related pain as another way to reduce the risk of learning and memory problems in survivors of childhood leukemia.

Lecture series logo
Lecture series logo
Investigator Insights

Rising Stars of Cancer Research lectures to bring fresh insights

Mary Powers

The Rising Stars of Cancer Research program is a new to the Science of Childhood Cancer lecture series. The program highlights the work of emerging leaders in the cancer research community.

global
global
Outreach

St. Jude Global Alliance holds third annual convening

Lance Wiedower

Empower Everyone was the theme of the St. Jude Global Alliance Convening, a virtual meeting that attracted participants from around the world.

CoNGA
CoNGA
Research

CoNGA: Deciphering the dance of T-cell differentiation

Stefan Schattgen, PhD

St. Jude scientists have created an algorithm to help group T-cells by their function by evaluating two different types of data, T-cell receptor sequences and gene expression.

Walter Hughes sits at a desk early in his career
Walter Hughes sits at a desk early in his career
Investigator Insights

St. Jude mourns the death of infectious diseases pioneer Walter Hughes, MD

Mike O’Kelly

Walter Hughes, MD, who established the St. Jude Department of Infectious Diseases and initiated pediatric AIDS research at the hospital, has died.

Haitao Pan, PhD
Haitao Pan, PhD
Research

St. Jude biostatisticians create a novel clinical trial design software

St. Jude Progress

Description: St. Jude biostatisticians have developed a new method for designing phase 2 clinical trials with a small sample size. The approach uses a mathematical model called Bayesian probability . The researchers created free software to implement the process.

Meeting graphic
Meeting graphic
Research

Bringing Chemistry to Medicine: Transcription therapy symposium is set for July 22 and 23

Mike O’Kelly

St. Jude will host the virtual Bringing Chemistry to Medicine Symposium July 22–23. The inaugural event in 2020 prompted a researcher in India to become a visiting scientist at St. Jude. Register for the event.

image of matches with one burnt in the middle
image of matches with one burnt in the middle
Clinical

When work takes a toll: St. Jude research adds to our understanding of physician burnout.

Jonathan Burlison and Lindsay Blazin

St. Jude researchers looked at burnout and perceived work demands among St. Jude physicians and found that emotional exhaustion and time demands are key factors in a problem that affects both provider and patient.

Stronger Together
Stronger Together
Investigator Insights

Connections with colleagues: A St. Jude pediatric psychologist has renewed appreciation for an overlooked benefit of interdisciplinary collaboration.

Elyse Heidelberg, PsyD

A pediatric psychologist expresses gratitude for interdisciplinary collaboration, which elevates patient care and provider well-being.

Martine Roussel, PhD, stands for a portrait with her lab blurred out in the background.
Martine Roussel, PhD, stands for a portrait with her lab blurred out in the background.
Investigator Insights

Roussel’s early discovery shaped a career of cancer research

St. Jude Communications Department

Martine Roussel, PhD, faculty member and endowed chair in molecular oncogenesis, shares how early work on oncogenes led to her lab’s discovery of new oncogenes.