Progress Pulse

Sequencing large-scale changes in DNA to detect cancer earlier

Discover how St. Jude scientists improved detection of large structural changes in DNA to identify cancer cells.

Expedited and accurate detection of targeted gene fusions with St. Jude Fuzzion2

Learn about Fuzzion2, the fuzzy pattern-matching program developed to detect targeted gene fusions with speed and accuracy.

Reducing the risk of cerebellar mutism syndrome through surgical guidelines

Read how surgeons aim to reduce posterior fossa syndrome risk

Global collaboration reduces preventable infections during pediatric cancer treatment

Learn how St. Jude Global Infectious Disease Program partnered with hospitals in Ecuador and Guatemala to reduce preventable infections in pediatric cancer units through local training.

Developmental window explains origin of non-muscle cell pediatric rhabdomyosarcoma

Discover how endothelial progenitors contribute to rhabdomyosarcoma and restrict the disease to childhood.

Model facilitates research on the second most common form of sickle cell disease

Explore new models of HbSC, which recapitulate the disease’s human symptoms and other pathologies, created by St. Jude research to find better treatments.

Study Provides Insights on Asparaginase-Associated Pancreatitis in Pediatric ALL

Explore the risk factors for asparaginase-associated pancreatitis and outcomes of asparaginase rechallenge.

Binding partners and cooperating mutations define NUP98 leukemia subtypes

See how one rearranged gene can lead to multiple leukemia subtypes

Early nutrient availability is a key driver of T-cell exhaustion

See how early nutrient availability influences T-cell exhaustion even in the early stages of T-cell activation.

NUTD5 forms the fulcrum of thiopurine toxicity and resistance

Understanding the protein’s role may unlock individual cancer and autoimmune therapies. Progress category: Pulse