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Combination therapy shows potential to treat pediatric brain cancer ATRT
12/16/2025
See how a combo therapy of idasantulin and Selinexor stimulate the p53 pathway through MDM2 and XPO1 to treat atypical teratoid rhabdoid tumors (ATRT)
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Accelerating drug combination discovery with machine learning
12/15/2025
Explore ComboCat, a St. Jude scientist-created system that combines machine learning and advanced liquid handling to speed up combination drug discovery.
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Membrane ‘neighborhood’ helps transporter protein regulate cell signaling
12/05/2025
See how protein kinase A, SCRIB, and other proteins help keep ABCC4 transporter levels steady in the membrane to regulate cyclic AMP signaling
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Research reveals how disordered protein regions contribute to cancer-causing condensates
12/03/2025
See how scientists use IDR-Puncta ML to predict which fusion oncoproteins form condensates, revealing new insights into cancer and RNA biology.
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Spatial Touchstone brings quality control to spatial transcriptomics
12/03/2025
Explore Spatial Touchstone’s open-source tools and data for standardized spatial transcriptomics, enabling reliable, cross-institutional gene expression analysis.
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Research reveals structural mechanism behind anti-epilepsy therapies
12/01/2025
Learn how epilepsy drugs reshape SV2A and how new modulators boost potency, paving the way for more effective epilepsy treatments.
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Inflammation and metabolic stress combine to drive a new cell death pathway: mitoxyperilysis
11/28/2025
Discover how St. Jude research uncovered an unknown cell death pathway triggered by innate immune activation and nutrient scarcity that may help treat cancer.
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St. Jude method democratizes access to T-cell receptor analysis
11/24/2025
Speed up analysis of T cells with the scalable and cost-effective TIRTL-sequencing method invented by St. Jude scientists, as published in Nature Methods.
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2025 Highly Cited Researchers list highlights St. Jude scientific impact
11/13/2025
St. Jude researchers among nationally recognized highly cited researchers
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AlphaSync database keeps protein structure prediction resource up to date
11/11/2025
Discover how St. Jude scientists created AlphaSync, a database that keeps protein predictions up to date to push science forward & prevents cascading errors.
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Pediatric Cancer Genome Project
Launched in 2010, the Pediatric Cancer Genome Project became the world’s most ambitious effort to discover the origins of pediatric cancer. Learn about its discoveries.