Director: John D. Crispino, PhD, MBA
The Division of Experimental Hematology encompasses the laboratory-based research within the Department of Hematology. Our mission is to make clinically relevant discoveries in non-malignant hematology. Current areas of interest include pharmacogenomics of sickle cell disease, gene therapy for hemophilia, hemoglobinopathies, and immunodeficiencies, and basic biology of hematopoietic stem cells. The Division is highly interactive with numerous collaborations between laboratories and prioritizes high quality translational research.
Genomic approaches to studying cis-regulatory modules in hematopoiesis
Vascular/hematopoietic development and leukemia
Inherited and acquired blood disorders
Cellular and molecular regulation of hematopoietic stem cell in vivo repopulating activity, hematopoietic stem cell development and specification.
Genome engineering technologies for therapeutics
Inherited bone marrow failure and MDS predisposition syndromes