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Explore our cutting edge research, world-class patient care, career opportunities and more.
St. Jude Children's Research Hospital Home
- Fundraising
Divisional focus
The mission of the Division of Pathology Research is to conduct and support basic and translational research into childhood catastrophic diseases to advance cures through innovations in diagnosis and treatment. The Division encompasses the Center of Excellence for Leukemia Studies (CELS), a St Jude Comprehensive Cancer Center initiative to recruit exceptional faculty who bring conceptual and technical innovation to the study of childhood hematological malignancies. Thus, the Division has a strong focus on understanding the genomic basis and biology of acute leukemia and bone marrow failure, but also brain tumors and immunotherapy.
The Division and CELS oversee substantial core facility resources, including flow cytometry and cell sorting, genomic and single-cell technologies, bioinformatics, metabolomics, and the Advanced Technologies in Genomics Core directed by CELS faculty member Jian Xu, PhD. The Division and its faculty are closely integrated with clinical activities in the Department and shared resources such as the Clinical Biomarkers Laboratory and the Preclinical Testing Program, and they make extensive use of tumor samples and clinical data.
Division resources
- St. Jude Biorepository
- Clinical Biomarkers Lab
- Advanced Technology and Genomics (ATG) Core
- PROPEL
- CELS flow/sorting core
- CELS genomics core
- CELS bioinformatics core
Director
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Charles G. Mullighan, MBBS (Hons), MSc, MD
Member, St. Jude Faculty
Senior Deputy Director of Strategic Initiatives, Comprehensive Cancer Center
Co-Leader, Hematological Malignancies Program
Medical Director, St. Jude Biorepository
William E. Evans Endowed Chair
Charles G. Mullighan, MBBS (Hons), MSc, MD
Member, St. Jude Faculty
Senior Deputy Director of Strategic Initiatives, Comprehensive Cancer Center
Co-Leader, Hematological Malignancies Program
Medical Director, St. Jude Biorepository
William E. Evans Endowed Chair
Affiliations
Research Interests
- The use of integrated genomic and epigenomic approaches to understand the pathogenesis and evolution of acute lymphoblastic leukemia (ALL) and related disorders
- Defining the interaction of inherited and somatic genetic alterations in leukemogenesis
- The use of in vitro and in vivo experimental approaches to model genomic abnormalities in leukemogenesis
- Preclinical therapeutic testing to translate genomic discoveries to new treatment approaches in ALL
Contact Information
Charles G. Mullighan, MBBS (Hons), MSc, MD
Pathology
MS 342, Room D4047D
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Faculty
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Jian Xu, PhD
Member, St. Jude Faculty
Research Interests
- Enhancer function and regulation in development and cancer
- Epigenetics-metabolism crosstalk in normal and disordered blood development
- Functional metabolism in hematopoiesis and hematologic disease
- System biology and multi-omic dissection of cancer evolution and therapy response
Contact Information
Jian Xu, PhD
Center of Excellence in Leukemia Studies (CELS)
MS 345
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, 38105-3678
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Gerard P. Zambetti, PhD
Member, St. Jude Faculty
Associate Director, Education and Training, Comprehensive Cancer Center
Gerard P. Zambetti, PhD
Member, St. Jude Faculty
Associate Director, Education and Training, Comprehensive Cancer Center
Affiliations
Research Interests
- Function of wild-type and mutant p53 in tumor suppression and oncogenesis
- Regulation of cell cycle, cell survival and differentiation
- The biology of pediatric adrenocortical carcinoma
Contact Information
Gerard P. Zambetti, PhD
Pathology
MS 276, Room D5006B
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Alyssa Lee Kennedy, MD, PhD
Assistant Member, St. Jude Faculty
Alyssa Lee Kennedy, MD, PhD
Assistant Member, St. Jude Faculty
Affiliations
Research Interests
- Inherited bone marrow failure disorders
- Clonal hematopoiesis
- Shwachman-Diamond Syndrome
- Discovery and developmental therapuetics
Contact Information
Alyssa Lee Kennedy, MD, PhD
Hematology
MS 344, Room D4007E
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Ruth Wang’ondu, MD, PhD
Instructor, St. Jude Faculty
Ruth Wang’ondu, MD, PhD
Instructor, St. Jude Faculty
Affiliations
Research Interests
- Using in vitro and in vivo models of B-Acute Lymphoblastic Leukemia to study effects of IKZF1 (Ikaros) alterations on leukemogenesis and drug resistance
- Defining effects of Ikaros alterations on prognostication and risk stratification of B-Acute Lymphoblastic Leukemia
- Integration of genetic data from diverse populations to inform treatment of B-Acute Lymphoblastic Leukemia
Contact Information
Ruth Wang’ondu, MD, PhD
Clinical Education & Training
MS 343, Room D4036
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Staff
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Qingsong Gao, PhD
Bioinformatics Research Scientist
Qingsong Gao, PhD
Bioinformatics Research Scientist
Affiliations
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Pankaj Ghate, PhD
Scientist
Pankaj Ghate, PhD
Scientist
Affiliations
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Petri Polonen, PhD
Postdoctoral Research Associate
Petri Polonen, PhD
Postdoctoral Research Associate
Affiliations
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Kasia Szoltysek, PhD
Postdoctoral Research Associate
Kasia Szoltysek, PhD
Postdoctoral Research Associate
Affiliations
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Lindsey E. Montefiori, PhD
Research Associate, St. Jude Faculty
Affiliations
Research Interests
- Lineage ambiguous leukemia
- Gene regulatory mechanisms of oncogenic transcription factor activity
- Developing novel approaches to therapeutically target oncogenic gene expression
Contact Information
Lindsey E. Montefiori, PhD
Departrment of Pathology
MS 342, Room 4007B
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Chun Shik Park, PhD
Scientist
Chun Shik Park, PhD
Scientist
Affiliations
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Yiming Wu
Scientist
Yiming Wu
Scientist
Affiliations
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Ilaria Iacobucci, PhD
Principal Scientist-Directing
Ilaria Iacobucci, PhD
Principal Scientist-Directing
Affiliations
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Yunchao Chang, PhD
Scientist
Yunchao Chang, PhD
Scientist
Affiliations
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Ruth Tatevossian, MD, PhD
Director, Clinical Biomarkers Lab
Ruth Tatevossian, MD, PhD
Director, Clinical Biomarkers Lab
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Contact Information
Ruth Tatevossian, MD, PhD
Diagnostic Biomarkers Shared Resource
MS 250, Room C4036
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Matt Lear
Director-SJ Biorepository
Matt Lear
Director-SJ Biorepository
Affiliations
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Sandi
Research Program Manager
Sandi
Research Program Manager
Affiliations
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Shobha Lakshmi
Director-Large Grant Development
Shobha Lakshmi
Director-Large Grant Development
Affiliations
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Huimei Wei, PhD
Lead Researcher-LR
Huimei Wei, PhD
Lead Researcher-LR
Affiliations
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