Research

Learn about published research as well as leading-edge basic and translational research initiatives from St. Jude laboratories.

Like kisMET: targeted therapy and radiation synergize in pediatric high-grade glioma

Erin Podolak, MA

Translational research from Suzanne Baker, PhD, and colleagues shows that targeted MET inhibitor capmatinib effectively crosses the blood-brain-barrier, synergizing with radiation to treat pediatric high-grade glioma.

The “tall tail” behind ultrafast endocytosis

Brian O'Flynn, PhD

 Dive into the latest findings on synaptic vesicle dynamics

Understanding the clinical outcomes of a rare but distinct low-grade glioma

Brian O'Flynn, PhD

Putting patients first offers holistic view of disease

Math behind the medicine

Brian O'Flynn, PhD and Jessie Newman

Explore how mathematics influences all that we do at St. Jude

The long and the short of the cell antenna

Brian O'Flynn, PhD

Explore the pathway linking Sonic Hedgehog signaling with cilium length

Exploring biomolecular condensate networks’ internal structure

Brian O'Flynn, PhD

See how molecular dynamics revealed the inhomogeneous nature of biomolecular condensates

Distinct molecular profiles lead to a better understanding of acute leukemia

Emilia Asante, PhD

Distinct molecular profiles in acute myeloid leukemia (AML) and T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LLy) with PICALM::MLLT10 (PM) fusions shed light on potential targeted therapies for improved outcomes.

A glimpse beyond life and death: Exploring the biology of the MICOS complex

Brian O'Flynn, PhD

See how new model offers glimpse into vital mitochondrial complex

Influenza virus provides first evidence of bats’ potential as an intermediate host

Alex Generous, PhD

Explore research showing bats may be an intermediate influenza host.

Blazing a TRAIL in acute myeloid leukemia treatment

Brian O'Flynn, PhD

See how studies into AML drug reveals new potential target