Research News & Publications

Comprehensive clinical sequencing opens door to the promise of precision medicine

07/23/2021

St. Jude Children’s Research Hospital study highlights the power of comprehensive whole genome, whole exome and RNA sequencing to better understand and treat each patient’s cancer.
Research illuminates earliest part of phase separation

07/23/2021

St. Jude scientists study how phase separation begins on a microsecond time scale, showing how the earliest events with individual molecules impact assembly speed.
Chemotherapy can induce mutations that lead to pediatric leukemia relapse

07/22/2021

A collaboration led by St. Jude Children’s Research Hospital, Shanghai Children’s Medical Center and others revealed how thiopurines produce mutations that lead to multi-drug resistant leukemia and relapse.
Molecular groups give context to clinical results

07/22/2021

St. Jude scientists looked at tumor samples from a Children’s Oncology Group clinical trial and assigned participants to molecular groups. The findings changed how the trial’s results were interpreted.
Scientists link frailty and neurocognitive decline in childhood cancer survivors

07/20/2021

St. Jude Children’s Research Hospital scientists have shown that frailty contributes to neurocognitive decline in young adult survivors of childhood cancer.
Visualizing moving molecules

07/07/2021

St. Jude researchers are trying to visualize and better understand the movements of the ribosome.
A pathway to balance revealed

07/07/2021

St. Jude scientists found a metabolic control pathway that regulates how specialized immune cells develop.
Genetic factors linked to response to common antiviral medications

07/07/2021

Scientists at St. Jude and international collaborators have shown that the enzyme NUDT15 metabolizes ganciclovir and acyclovir, with genetic variants in this gene affecting how patients respond to these drugs.
Melanoma registry results shine light on rare pediatric cancer

07/06/2021

St. Jude Children’s Research Hospital scientists created a registry for molecular analysis of pediatric melanoma that provides insight into treatment.
Studies reveal key process needed for cells to recover from stress

06/24/2021

A pair of papers from St. Jude Children’s Research Hospital shows ubiquitination is needed for disassembly of stress granules, which are linked to neurodegenerative diseases.