Departmental Focus
Scientists in the Department of Developmental Neurobiology investigate the fundamental processes that govern normal brain development and function. We believe that this information will provide unique opportunities for understanding and treating a range of diseases afflicting the nervous system including tumors, defects in hearing and vision as well as neurodegenerative and psychiatric disorders. Our goal to enhance novel clinical therapies is facilitated by fostering an interactive environment where researchers investigating fundamental aspects of nervous system development and function of neural circuits are juxtaposed to those engaged in clinical and translational research. Indeed, faculty in the department hold key leadership positions in two of the institutional Comprehensive Cancer Center Programs: the Neurobiology and Brain Tumor Program and the Developmental Biology and Solid Tumor Program; each recognized for its basic, translational and clinical research into tumors afflicting children. To further strengthen translational interactions and fundamental research, the department hosts two divisions, Brain Tumor Research and Neural Circuits and Behavior, whose research efforts are complimentalry to the goals of the CCC.
Current research includes studies of early cell fate decisions and control of brain growth, neuronal migration and synapse formation, analysis of the mechanisms responsible for synaptic plasticity, neural circuit function and animal behavior, investigations of the control of cell death and regeneration, examination of mechanisms in neurodegenerative diseases, identification of genes involved in the formation and function of the retina, and elucidation of the molecular mechanisms underlying a range of tumors, including medulloblastoma, neuroblastoma, retinoblastoma, ependymoma and glioma. These investigations are further leveraged by our use of multiple experimental platforms that range from comprehensive genomics and proteomics to advanced cellular and in vivo imaging and computational biology to derivation of novel genetic preclinical models of childhood diseases.
Contact Us
Department of Developmental Neurobiology
MS 323, Room D2025
St. Jude Children’s Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678 USA
Email: michael.dyer@stjude.org
Phone: (901) 595-6195
Fax: (901) 595-3066
Preferred contact method: email
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Suzanne J. Baker, PhD
Baker
Molecular, cellular and developmental pathogenesis of pediatric high-grade glioma
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Jay B. Bikoff, PhD
Bikoff
Functional organization of spinal interneurons
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Xinwei Cao, PhD
Cao
Growth control during neural tube development
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Fabio Demontis, PhD
Demontis
Mechanisms of skeletal muscle aging, protein homeostasis, and myokines
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Michael Dyer, PhD
Dyer
Retinal development and retinoblastoma
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Regulatory mechanisms of neural progenitors in brain development, diseases, & evolution
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Khaled Khairy, PhD
Khairy
Computational models of membrane-bound structures, and priors in biological image analysis
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Myriam Labelle, PhD
Labelle
The role of the microenvironment in cancer metastasis
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Stephen C. Mack, PhD
Mack
Pediatric brain tumors; cancer epigenetics; therapeutics; models
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James I. Morgan, PhD
Morgan
Control of neuronal death and differentiation
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Paul A. Northcott, PhD
Northcott
Integrative genomics and molecular features of pediatric brain tumors
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Jamy C. Peng, PhD
Peng
Epigenetic regulation of stem cell functions
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Junmin Peng, PhD
Peng
Proteomics to ubiquitin biology and human disease
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Jasmine Plummer, PhD
Plummer
Spatial Omics
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Lindsay Schwarz, PhD
Schwarz
Molecular and organizational diversity of neuromodulatory circuits and their role in neuropsychiatric disease
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David J. Solecki, PhD
Solecki
Cell polarity in neuron precursor differentiation
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Elizabeth A. Stewart, MD
Stewart
High risk pediatric solid tumors
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Jason D. Vevea, PhD
Vevea
Molecular mechanisms of the synaptic vesicle cycle
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Stanislav S. Zakharenko, MD, PhD
Zakharenko
Neural circuits of learning, memory and their dysfunction in neuropsychiatric disease