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St. Jude Children's Research Hospital Home
St. Jude Family of Websites
Explore our cutting edge research, world-class patient care, career opportunities and more.
St. Jude Children's Research Hospital Home
Improving the therapeutic ratio of therapy for children with catastrophic diseases
Improving the lives of children with catastrophic diseases requires a continual refinement of our treatment modalities through clinical practices and research. The heart of my work centers on improving the delivery of radiotherapy both alone and in combination with other modalities. Our goal is to personalize care for individual patients to prevent complications from cancer therapy and improve disease control. My multifaceted interests, which range from developing and applying innovative technologies to fostering a deeper understanding of disease biology, contribute to my commitment to improve the lives of children with cancer.
As we strive to optimize treatments and provide personalized care for pediatric patients, my work takes a multifactorial approach that spans several areas. My involvement in clinical trials has led to dose de-escalation for patients with high-risk neuroblastoma and the evaluation of proton therapy’s role in acute and late effects in childhood cancer survivors. My partnership with St. Jude Global has led me to consult on global tumor boards and mentor developing pediatric radiation oncologists from across the world, which has significantly expanded my skillset and potential for contribution as a radiation oncologist.
Moving forward, my efforts will continue across multiple areas to ensure St. Jude remains a leader in radiotherapeutic approaches that maximize quality of life and minimize long-term effects. Building on my work with St. Jude Global, I contribute actively to the development of international guidelines, which are resource stratified for low- and middle-income countries specifically for Hodgkin lymphoma, neuroblastoma, acute lymphoblastic leukemia and supportive care for radiation-related side effects.
In the clinical trials space, I continue to design and develop trials that prospectively evaluate the therapeutic ratio of radiotherapy in various settings for several childhood cancers with the goal of minimizing toxicity and maximizing disease control. To comprehensively evaluate the role of genetics in treatment efficacy, I work collaboratively with the Departments of Pathology, Computational Biology and the Division of Cancer Predisposition with the aim of correlating germline and tumor genetic characteristics to the risk of treatment-related injury and treatment failure. By conducting clinical research across these focus areas, my hope is that our work improves the quality of life for children with childhood cancer, both as they receive treatment and as they transition out of the treatment phase to life as a survivor.
Dr. John T. Lucas Jr. is a board-certified radiation oncologist with a dedication to pediatric radiation oncology and translational research. As an associate member at St. Jude, Dr. Lucas leverages his expertise in advanced biomolecular techniques, imaging analysis and clinical trial design to offer new interventions and insights in the context of therapeutic and non-therapeutic trails. He also designs complex trials, analyzes rare pediatric tumors and refines treatment/surveillance for late effects in childhood cancer survivors. These pillars of clinical work and research have emboldened Dr. Lucas’s deep passion for childhood cancer patients and have fueled his contributions across the institution, to national cooperative groups and in international global childhood cancer initiatives.
John T. Lucas Jr., MS, MD
Associate Member
Department of Radiation Oncology
MS 210, Room I3126
St. Jude Children's Research Hospital