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St. Jude Children's Research Hospital Home
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St. Jude Family of Websites
Explore our cutting edge research, world-class patient care, career opportunities and more.
St. Jude Children's Research Hospital Home
- Fundraising
Goal: Identify and translate innovative targets in immuno-oncology, ultimately enabling and advancing curative therapies for pediatric cancers and other catastrophic diseases.
Impact: This project will build a transformative model for translating data-driven discoveries in silico to preclinical validations at the bench and then to early clinical trials at the bedside by bridging immunology, systems biology, cancer biology, preclinical modeling, and clinical investigation.
Research Team
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Hongbo Chi, PhD
Member, St. Jude Faculty
Chair, Department of Immunology
Robert G. Webster Endowed Chair in Immunology
Co-Director, Center of Excellence for Pediatric Immuno-Oncology (CEPIO)
Associate Director, Basic Science, Comprehensive Cancer Center
Hongbo Chi, PhD
Member, St. Jude Faculty
Chair, Department of Immunology
Robert G. Webster Endowed Chair in Immunology
Co-Director, Center of Excellence for Pediatric Immuno-Oncology (CEPIO)
Associate Director, Basic Science, Comprehensive Cancer Center
Affiliations
Research Interests
- Studying how metabolism influences immune cell fate and function, including T cells and dendritic cells
- Exploring nutrient signaling pathways in T-cell quiescence, quiescence exit, and differentiation
- Using in vivo CRISPR screens and multi-omics systems tools to identify targets for reprogramming T-cell function and overcoming tumor immune evasion
- Applying genetic and immunometabolic engineering and therapeutic translation to improve immunotherapy for cancer and immune-mediated diseases
Short Biography
Investigating immune cell metabolism (immunometabolism) in T cell biology, systems immunology and human disease
Contact Information
Hongbo Chi, PhD
Immunology
MS 351, Room M5424
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Jiyang Yu, PhD
Member, St. Jude Faculty
Interim Chair, Department of Computational Biology
Jiyang Yu, PhD
Member, St. Jude Faculty
Interim Chair, Department of Computational Biology
Affiliations
Research Interests
- Systems biology and immunology
- Single-cell and spatial systems biology
- Immuno-oncology
- Translational research
Contact Information
Jiyang Yu, PhD
Computational Biology
MS 1135, Room IA6053
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Terrence Geiger, MD, PhD
Member, St. Jude Faculty
Senior Vice President and Deputy Director for Academic and Biomedical Operations
St. Jude Endowed Chair in Pediatrics
Terrence Geiger, MD, PhD
Member, St. Jude Faculty
Senior Vice President and Deputy Director for Academic and Biomedical Operations
St. Jude Endowed Chair in Pediatrics
Affiliations
Research Interests
- Immune regulation
- Autoimmunity
- Cellular immunotherapy
- Clinical pathology
- Transfusion medicine and apheresis
Contact Information
Terrence Geiger, MD, PhD
Administration
MS 275, Room C7015
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Stephen Gottschalk, MD
Member, St. Jude Faculty
Chair, Department of Bone Marrow Transplantation & Cellular Therapy
Co-Director, Center of Excellence for Pediatric Immuno-Oncology (CEPIO)
Endowed Chair in Bone Marrow Transplantation & Cellular Therapy
Stephen Gottschalk, MD
Member, St. Jude Faculty
Chair, Department of Bone Marrow Transplantation & Cellular Therapy
Co-Director, Center of Excellence for Pediatric Immuno-Oncology (CEPIO)
Endowed Chair in Bone Marrow Transplantation & Cellular Therapy
Affiliations
Research Interests
- Cancer immunotherapy
- Cell therapy
- Stem cell transplantation
Short Biography
Exploring translational immune-oncology and immunotherapy for pediatric cancer
Contact Information
Stephen Gottschalk, MD
Bone Marrow Transplantation and Cellular Therapy
MS 321, Room I4112
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
