2021 Archive

St. Jude On

The circuitous path from chemical compound to clinical trial

Heather Johnson

St. Jude scientists are making progress in the treatment of pediatric cancer by translating new drug findings from the lab to the clinic.

Investigator Insights

5 Questions for Andrew Kleist, MD, PhD

Andrew Kleist, MD, PhD and Alex Generous, PhD

Meet Andew Kleist, MD, PhD, a 2025 STAT Wunderkind early career scientist.

Research

Genomic Medicine Initiative (GEMINI) targets unmet needs in rare disease treatment

Jake Hopkins, MBA and Brian O'Flynn, PhD

Learn how GEMINI addresses the challenges of rare genetic diseases

Investigator Insights

Navigating a non-traditional path to becoming a scientist

Matthew Fisher

Meet graduate student Matthew Fisher to learn about his atypical scientific career progression.

Clinical

St. Jude calculators crunch the numbers to empower survivors of childhood cancer

Alex Generous, PhD

Find about these free resources, which scientists keep current with the most current survivorship research.

Investigator Insights

Finding my path from baseball to biomedical science

Jordan Bondrowski

A chance encounter at a baseball game as a child set Jordan Bondrowski on the path toward becoming a student in the St. Jude Graduate School of Biomedical Sciences.

Research

Demystifying a methylation mystery at the fetal hemoglobin gene promoter

Alex Generous, PhD

Learn how St. Jude scientists answered a decades-old mystery with implications for sickle cell anemia and beta thalassemia treatment.

Clinical

Harnessing the power of PET to diagnose infectious disease

Kathryn J. McCullough, MA

In a first-in-human trial, investigators at St. Jude are using the power of PET paired with novel radiotracer, [18F]fluoromannitol, to diagnose bacterial infections in patients.

Investigator Insights

5 Questions for Vivian Lawrence, RN

Vivian Lawrence, RN and Kathryn J. McCullough, MA

Meet Vivian Lawrence, RN, Department of Pediatric Medicine, and learn about her career path in clinical research at St. Jude.

Research

Center of Excellence in Pediatric Immuno-Oncology fast-tracks progress from the lab to the clinic

Alex Generous, PhD

Learn how St. Jude is accelerating immunotherapy research through communication.

Investigator Insights

St. Jude mourns the death of infectious diseases pioneer Walter Hughes, MD

Mike O’Kelly

Walter Hughes, MD, who established the St. Jude Department of Infectious Diseases and initiated pediatric AIDS research at the hospital, has died.

Research

St. Jude biostatisticians create a novel clinical trial design software

St. Jude Progress

St. Jude biostatisticians have developed a new method for designing phase 2 clinical trials with a small sample size. The approach uses a mathematical model called Bayesian probability . The researchers created free software to implement the process.

Research

Bringing Chemistry to Medicine: Transcription therapy symposium is set for July 22 and 23

Mike O’Kelly

St. Jude will host the virtual Bringing Chemistry to Medicine Symposium July 22–23. The inaugural event in 2020 prompted a researcher in India to become a visiting scientist at St. Jude. Register for the event.

Clinical

When work takes a toll: St. Jude research adds to our understanding of physician burnout.

Jonathan Burlison and Lindsay Blazin

St. Jude researchers looked at burnout and perceived work demands among St. Jude physicians and found that emotional exhaustion and time demands are key factors in a problem that affects both provider and patient.

Investigator Insights

Connections with colleagues: A St. Jude pediatric psychologist has renewed appreciation for an overlooked benefit of interdisciplinary collaboration.

Elyse Heidelberg, PsyD

A pediatric psychologist expresses gratitude for interdisciplinary collaboration, which elevates patient care and provider well-being.

Investigator Insights

Roussel’s early discovery shaped a career of cancer research

St. Jude Communications Department

Martine Roussel, PhD, faculty member and endowed chair in molecular oncogenesis, shares how early work on oncogenes led to her lab’s discovery of new oncogenes.

Research

Identifying risks and restrictions: Rehabilitation and cancer survivorship

St. Jude Communications Department

Kristin Lyons, director of Rehabilitation Services, and Jessica Sparrow, Lead Occupational Therapist, worked as part of a team of oncology rehabilitation providers from pediatric institutions across the country to co-author a recent Seminars in Oncology Nursing article, which provides a comprehensive overview of rehabilitation screening, assessment, and intervention for children with cancer.

Research

Getting to the bottom of a medulloblastoma mystery

Erin Podolak, MA

Posterior fossa syndrome develops in some children following surgery for the brain tumor medulloblastoma. St. Jude research offers fresh insight into the mysterious syndrome and advice on how to avoid it.

Clinical

NCCN publishes guidelines for standardized treatment of Wilms tumor

St. Jude Strategic Communication, Education and Outreach Department

The National Comprehensive Cancer Network recently published treatment guidelines for children diagnosed with nephroblastoma. Two St. Jude physicians collaborated on the project.

Research

For the growing number of childhood cancer survivors, five-year survival is just the beginning

AnnaLynn Williams, PhD

As cancer survivorship changes, new benchmarks must be set to redefine survivorship research and treatment success.