Evaluating pediatric cancer through the lens of time New study accounts for years of life lost due to cancer. It’s the first time this metric has been used to analyze the childhood cancer burden globally. Learning from rare disorders Science Advances highlights St. Jude research into rare inherited Lysosomal disorders caused by mutations in the NEU1 gene. Researchers discover key genetic trigger that compromises cancer immunotherapy T cell exhaustion has proven to be an obstacle for immunotherapy, and investigators hope their basic findings will result in techniques to prevent exhaustion. Scientists follow the data to a surprise Researchers surveyed the accumulation of toxic proteins in Alzheimer’s models, and discovered that a pathway nicknamed LANDO can limit the protein buildup. Studying single cells to understand a type of pediatric brain tumor Scientists completed the most in-depth study of medulloblastoma subtypes by studying single cells to help shed light on how cells become cancerous. BRCA2 gene linked to risk of non-Hodgkin lymphoma A St. Jude study linked inherited mutations in the BRCA2 gene with a higher risk of non-Hodgkin lymphoma. Autumn 2019 Table of Contents Subscribe to Promise Full Name Email* Submit Share through Facebook Twitter LinkedIn E-Mail Share Close From Promise, Autumn 2019 Donate Now Subscribe to Promise Name: Email: Message: Submit Feedback Thank you for your feedback! More articles from this issue St. Jude LIFE Celebrates Milestone St. Jude welcomes its 5,000th patient back to campus in an extraordinary study designed to help the survivors of today and the children of tomorrow. Blue-Sky Projects Accelerate Progress St. Jude identifies and pursues bold new projects that could transform science and medicine. Where Leukemia Hides, the Immune System Seeks Research challenges the notion that cancer cells must contain multiple mutations to prompt an immune response. It's a BRAVE New World for Mobility The new BRAVE (Beginning Restorative Activities Very Early) program seeks to help mobilized patients as soon as possible to decrease their time in the pediatric intensive care unit and reduce delirium and ventilation time. Together: Powered by St. Jude A new website brings families and St. Jude experts together to face pediatric cancer. This online resource offers trustworthy resources for families around the world to learn about childhood cancer. Global Child Health: Spreading Knowledge, Saving Children A unique Master of Science in Global Child Health trains health care professionals around the world. This program incorporates the world-renowned faculty of the St. Jude Children’s Research Hospital Graduate School of Biomedical Sciences with the expertise of faculty in Global Pediatric Medicine. Half-Matched Transplants, Whole Hope for Cures A new study for half-matched transplants aims to cure high-risk blood cancers. The HAP2HCT clinical trial aims to kill remaining cancer cells, reduce the risk of GVHD and help patients’ immune systems recover quickly. Organizing Organelles How do cells organize proteins without membranes? St. Jude scientists unlock the mysteries of liquid-liquid phase separation, or LLPS, to better understand membraneless organelles. Life after St. Jude: Hoop Dreams Learn about the global cancer burden in low- and middle-income countries, what we can learn from rare disorders, new findings about the BRACA2 gene, and other recent scientific discoveries. Super-conducting Magnet St. Jude takes delivery of the world’s largest superconducting magnet. Creative Approach to Discovery Eric Enemark, PhD, uses his imagination to create a simple model to illustrate a complex principle.