Pre-clinical research is a key and necessary step in the development of childhood cancer treatments. The primary goal of pre-clinical research is to identify new agents that have the potential for significant activity when clinically evaluated against selected childhood cancers. It is very unlikely that a new agent will be tested in patients without being tested and shown to be efficacious in an animal model. Thus, the choice of appropriate animal model and the experimental endpoints to assess the effectiveness of a new agent is crucial.
The pre-clinical division of Biostatistics is essential to the successful of St. Jude pre-clinical research. Individuals in the pre-clinical division of Biostatistics provide expertise to the investigators in the areas of pre-clinical trial design and statistical analyses. The strength of the pre-clinical division of Biostatistics is that its staff has strong collaborative experience in preclinical in vitro and in vivo tumor xenograft experiments and a strong methodological research record closely linked to statistical issues in the trial design and data analysis of pre-clinical research. This further assures its ability to provide the best statistical science to the St. Jude pre-clinical research program.
Division of Pre-Clinical Research
MS 768, Room R6033
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Phone: (901) 595-3372
Fax: (901) 595-8843
Clinical trials, robust methods, survival analysis